Antimalarial activities of Breynia Nivosa
Journal Title: Journal of Herbal Drugs - Year 2015, Vol 5, Issue 4
Abstract
Background & Aim: Antiplasmodial activity of leaf extract of Breynia nivosa was evaluated to ascertain the folkloric claim of its antimalarial activity. Experimental: The crude leaf extract (75 – 225 mg/kg), of Breynia nivosa was investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice. The antiplasmodial activity during early and established infections as well as prophylactic were investigated. Artesunate 5 mg/kg and pyrimethamine 1.2 mg/kg were used as positive controls. Thin films made from tail blood of each mouse were used to assess the level of parasitaemia of the mice. Results & Discussion: The extract dose-dependently reduced parasitaemia induced by chloroquine sensitive Plasmodium berghei infection in prophylactic, suppressive and curative models in mice. These reductions were statistically significant (p<0.001). They also improved the mean survival time (MST) from 11 to 27 days relative to control (p<0.01 – 0.001). The activities of extract was comparable to that of the standard drugs used (pyrimethamine). The antiplasmodial and antipyretic effects may in part be mediated through the chemical constituents of the plant. Industrial and practical recommendations: The plant, Breynia nivosa, possesses antimalarial property which can be exploited in the treatment of malaria.
Authors and Affiliations
Jude E. Okokon; koofreh Davis; Azare B. A
Keywords
Related Articles
- EP ID EP23459
- DOI -
- Views 325
- Downloads 19
The comparison of anti-diarrhea effects of two herbal compounds namely Elaeagnus Angustifolia (Oleaster) and Plantago major powders in Dogs
Background & Aim:Increasing the tendency in families for taking care of pets makes people pay more attention to their disease especially the common ones. In recent years the tendency to use herbal drugs has increased...
Chemical composition of the essential oils Ziziphora clinopodioides collected from Tuyserkan (Hamadan), Iran
Background & Aim: Ziziphora clinopodioides Lam (Kakuty-e-Kohi) is an aromatic and medicinal plant belonging to the family Labiaceae. The essential from this species contains pulegune that having effects such as sedative,...
Identification of the chemical components of (Salvia spinosa L.) in Isfahan climatic conditions
Background & Aim: (Salvia spinosa L.) is perennial shrub and aromatic plant belongs to Lamiaceae family. S.spinosa growing wild in Iran. The aim of this study was to identify of the chemical components of S.spinosa in...
Anti-inflammatory activity of leaf extract of Solanum anomalum
Background & Aim: Solanum anomalum Thonn. ex Schumach. (family Solanaceae) is a shrub growing up to 2 metres tall. The edible fruits are gathered from the wild and consumed locally and the leaves are used locally in t...
The effect of ethanolic and aqueous extracts of Berberies vulgaris on multidrug- resistant gram-negative pathogenic bacteria
Background and Aim: In recent years, due to the indiscriminate and irrational use of synthetic drugs, the resistance of pathogenic microorganisms has increased; therefore, new compounds are vitally needed. The purpose...