Antimicrobial Activity of Phenylpropanoyle from the Rhizome of Zingiber officinale Roscoe (Zingiberaceae)
Journal Title: European Journal of Medicinal Plants - Year 2014, Vol 4, Issue 2
Abstract
Aim: This study was carried out to determine the phytochemical and the antimicrobial activities of Zingiber officinale (Zingiberaceae) Rhizome. Methodology: The air-dried and powdered rhizome (1.0 kg) of Z. officinale was extracted with ethyl acetate (1.5 L) at room temperature for 72 h. After evaporation under reduced pressure, 46.5 g of crude extract was obtained. The CH2Cl2 extract was purified by column chromatography over silica gel 60 (230-400 mesh) and preparative TLC using a gradient system of hexane, ethyl acetate and MeOH. Agar diffusion test plates with Escherichia coli CIP 548, Listeria monocytogenes CIP 82110, Enterococcus faecalis CIP 76117, Bacillus cereus CIP 6624, Staphylococcus aureus CIP 7625, Pseudomonas fluorescents CIP 6913, Bacillus substilis ATCC 6636, Candida lusitaniae ATCC 200950, Candida tropicalis ATCC 750, Cryptococcus neoformans CIP 95026, Aspergillus flavus, and Aspergillus parasiticus as test strains were performed. Results: A new nonyl-3-phenylpropanoate (1), together with known compounds, 8-hepthyl-12- propyldecanol (2) were isolated from the ethyl acetate extract of the rhizome of Zingiber officinale. The structures of the two compounds were determined by comprehensive analyses of their 1D and 2D NMR, mass spectral data, chemical reactions, and comparison with previously known analogue. The two compounds isolated from ethyl acetate extract showed antibacterial and antifungal activity and the Minimal Inhibitory Concentration (MIC) against the test fungi varied from 3.34 mM to 5.08 mM for compound 1 and from 3.81 mM to 5.08 mM for compound 2. Conclusion: One new compound, nonyl-3-phenylpropanoate, isolated from ethyl acetate extract of Zingiber officinale rhizome exhibited antibacterial and antifungal activities.
Authors and Affiliations
Talla Emmanuel, Bealem Aristide, Tatsadjieu Ngoune Leopold, Ngassoum Martin Benoît, Wansi Jean Duplex, Yaya Gbaveng, Dabole Bernard, Meli Alain, Mbafor Tanyi Joseph, Alain Roch
Keywords
Related Articles
- EP ID EP350005
- DOI 10.9734/EJMP/2014/6884
- Views 100
- Downloads 0
Evaluation of Wound Healing Activity of Erythrophleum suaveolens (Guill. & Perr.) Brenan and Moringa oleifera Lam. On Infected Albino Rats
Introduction: Erythrophleum suaveolens (Guill. & Perr.) Brenan (Caesalpiniaceae) and Moringa oleifera Lam. (Moringaceae) are important medicinal plants that have been reported to possess various medicinal properties incl...
Antibacterial Activity and Phytochemical Screening of Goniothalamus sesquipedalis (Wall.) Hook. f. & Thomson Extracts from Manipur, North East India
Aims: To screen the phytochemical constituents and study the antibacterial properties of the Goniothalamus sesquipedalis (Wall.) Hook.f. & Thomson used in the traditional medicine in the North East India. Place and Durat...
Observations on Flowering and Fruiting in Commiphora wightii (Arnott) Bhandari
The present work aims to document the phenological diversity of flowering and fruiting in guggul with reference to climate. Commiphora wightii flowering and fruiting patterns were monitored in Kaylana (Jodhpur, Rajasthan...
Stress Effects of TiO2 and NP-TiO2 on Catalase Enzyme and some Physiological Characteristics of Melissa officinalis L.
Aims: Today, detection of risk effects of metal and metal nanoparticles over environment has attracted much attention. Plants are always exposed to considerable nanoparticles. So we decided to study the stress effect of...
The Effects of Zinc Application and Cutting on Growth, Herb, Essential Oil and Flavonoids in Three Medicinal Lamiaceae Plants
Aims: The objective of this study was to investigate the effect of zinc on growth, fresh herb, essential oil and flavonoids content of Dracocephalum moldavica, Hyssopus officinalis and Salvia officinalis plants at two su...