ANTIMICROBIAL ACTIVITY OF PREGNENOLONE-CARBAMAZEPINE COMPLEX ON S. AUREUS, K. PNEUMONIAE AND E. COLI
Journal Title: International Journal of Pharmaceutical Sciences Review and Research - Year 2010, Vol 4, Issue 1
Abstract
In this work the antibacterial activity of pregnenolone-carbamazepine complex was evaluated on S. Aureus, K. pneumoniae and E. coli. The evaluation of antimicrobial effect of the different compounds on the bacterial species was made by the method of microbial minimal inhibitory. The results indicate that bacterial growth of S. Aureus was inhibited with cefotaxime (MIC=5.23 x 10-4 mmol), gentamicin (MIC=2.68 x 10-5 mmol), ciprofloxacin (MIC=3.77 x 10-4 mmol), hemisuccinate-pregnenolone (MIC=2.40 x 10-3 mmol), carbamazepine-aminocapric acid (MIC=6.80 x 10-4 mmol) and the pregnenolone-carbamazepine complex (MIC=1.39 x 10-4 mmol). Other results showed that bacterial growth of E. coli was inhibited with cefotaxime (MIC=5.23 x 10-4 mmol), gentamicin (MIC=1.34 x 10-5 mmol), ciprofloxacin (MIC=3.01 x 10-3 mmol), hemisuccinate-pregnenolone (MIC=2.40 x 10-3 mmol), carbamazepine-aminocapric acid (MIC=1.36 x 10-3 mmol) and the pregnenolone-carbamazepine complex (MIC=3.18 x 10-4 mmol). Alternative experimental, indicate that bacterial growth of K. pneumoniae was inhibited with cefotaxime (MIC=2.61 x 10-4 mmol), gentamicin (MIC=2.68 x 10-5 mmol), ciprofloxacin (MIC=1.50 x 10-3 mmol), hemisuccinate-pregnenolone (MIC=2.40 x 10-3 mmol), carbamazepine-aminocapric acid (MIC=1.36 x 10-3 mmol) and the pregnenolone-carbamazepine complex (MIC=3.18 x 10-4 mmol). In conclusion, S. Aureus, K. pneumoniae and E. Coli were more susceptible to both gentamicin and pregnenenolone-carbamazepine complex and were more resistant to that hemisuccinate-pregnenenolone conjugate. Possibly the molecular mechanism of pregnenolone-carbamazepine could be by mimic the actions of several steroid-derivates with antibacterial characteristics.
Authors and Affiliations
Lauro Valverde, Francisco Díaz-Cedillo, María Ramos, Elodia Cervera, Rogaciano Torres-Cruz, Jorge Reyna-Moo
Keywords
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