Antimicrobial efficacy of curcumin on periodontopathic microorganisms: An In-vitro study
Journal Title: IP International Journal of Periodontology and Implantology - Year 2018, Vol 3, Issue 3
Abstract
Objectives The present study was designed to analyse the effect of curcumin on certain periodontopathic pathogens in vitroMaterial and Methods 25 Curcumin was employed to analyze its Minimal Inhibitory Concentration MIC potential against the selected microorganismsGram negative oral bacterial strains which included primary colonizers namely Aggregatebacter actinomycetemcomitans Streptococcus mitis Streptococcus sanguis and secondary colonizers which are Porphyromonas gingivalis Tannerella forsythia Fusobacterium nucleatum and Prevotellainter media were cultured using thioglycollate growth medium under anaerobic conditions Broth microdilution susceptibility test method was employed in order to determine the antimicrobial effectiveness of bacterial responses at growing dilutions of curcumin After incubation in tubes the antibacterial activity of curcumin was detected by the lack of turbidity which indicated the inhibition of bacterial growthResults The curcumin MIC values were 126 gmL 25 gmL 50 gmL 50 gmL 04 gmL 25 gmL and 50 gmL against P gingivalis P intermedia T forsythia F nucleatum A actinomycetemcomitans S sanguis and S mitis respectivelyConclusions Curcumin inhibited the growth of all the selected bacterial strains at growing dilutions and is therefore a potent agent against periodontal diseases There is a need for further in vivo studies to assess the experimental observations on antibacterial effects of curcuminKeywords Curcumin Mean Inhibitory Concentration Periodontitis Anti inflammatory Optical Density
Authors and Affiliations
Keshava A. , Payal Chaudhari, Jinal Koli, Siddhartha V.
Keywords
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- EP ID EP520593
- DOI 10.18231/2457-0087.2018.0022
- Views 62
- Downloads 0
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