Antimicrobial peptides in asthma pathogenesis
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2015, Vol 69, Issue 0
Abstract
Antimicrobial peptides exhibit activity against bacteria, viruses, fungi, and parasites. They have been described not only as endogenous antibiotics but also as immune modulators with an impact on innate and adaptive immune functions. Asthma is one of the most common diseases, characterized by chronic airway inflammation, bronchial hyperreactivity and asthma attacks. Airway inflammation in asthma is characterized by allergic phenotypes, such as dense infiltration of eosinophils, mast cells, Th 2 lymphocytes and monocytes. Viral infections are often the cause of asthma exacerbation. This review highlights recent observations on the role of antimicrobial peptides in asthma pathogenesis.
Authors and Affiliations
Krzysztof Pałgan, Marta Tykwińska, Zbigniew Bartuzi
Keywords
Related Articles
- EP ID EP67570
- DOI -
- Views 136
- Downloads 0
Wpływ bakteriofagów na ekspresję genów mających udział w odporności przeciwdrobnoustrojowej
Introduction: Bacteriophages (viruses of bacteria) are used in the treatment of antibiotic‑resistant infections. Moreover, they are an important component of the mucosal microbiota. The objective of this study was to inv...
Mycolic acids – potential biomarkers of opportunistic infections caused by bacteria of the suborder Corynebacterineae
Mycolic acids are one of the basic elements of the cell wall structure of bacteria belonging to the suborder Corynebacterineae, constituting from 20% to 40% of dry weight. Additionally, they show high structural diversi...
Replikacja wirusa zapalenia wątroby typu C (HCV) w jednojądrowych komórkach krwi obwodowej (PBMC) u pacjentów z przewlekłym zapaleniem wątroby typu C, leczonych pegylowanym interferonem alfa i rybawiryną
Plant and microbial sources of antioxidants
In recent years there has been growing interest in substances with antioxidative properties, which reduce or prevent harmful effects of free radicals on living tissues, and inhibit aging processes and the development of...
Wpływ polimorfizmów genu IL18 na stężenie mRNA oraz wydzielanie interleukiny 18 przez jednojądrzaste komórki krwi obwodowej
IL-18 jest plejotropową cytokiną odgrywającą istotną rolę w modulowaniu odpowiedzi immunologicznej i w patogenezie wielu schorzeń o podłożu zapalnym. W pracy opisano związek między 7 jednonukleotydowymi polimorfizmami w...