Antimicrobial resistance pattern of uropathogenicEsch.coli - A three year retrospective study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5
Abstract
The Multidrug-resistant Escherichia coli (MDR Esch. coli) has emerged as a major cause of health care associated infections. They hydrolyze all beta-lactam antibiotics including extended-spectrum cephalosporins and carbapenems, not inhibited by serine beta-lactamase inhibitors like clavulanic acid, sulbactam, and tazobactam and are resistant to many antibiotics. UTIs caused by MDR Esch.coliis a cause of concern due to the decreasing clinical treatment protocols. The aim of this study was to determine the type and antibiotic resistance pattern of the urinary pathogens isolated from patients attending a busy tertiary care teaching institute of Malwa region of Punjab. A total number of 29848 urine samples were collected from R.H Patiala and processed in the Department of Microbiology G.M.C Patiala (Jan. 2014 to Dec2016). These isolates were screened for the detection of ESBL and carbapenemase production by the disc diffusion methods. The retrospective data was analysed of 3850 culture positive urine samples out of which 3061 were Esch.coli. Out of 3061Esch.coli, 1113 Esch.coli were Multi Drug Resistant. Out of 1113, 786 (70.6%) isolates were ESBL-positive, 48(21.3%) were MBL positive and 14 (1.0%) were both ESBL and MBL producers by phenotypic methods. The high levels of resistance to different antibiotics showedthat treatment options are limited and that infection control measures remain of high importance. Drug-resistance surveillance is needed periodically by phenotypic method where molecular techniques are not available for implementation of national UTI Guidelines.
Authors and Affiliations
Dr. Rupinder Bakshi, Dr. Geeta Walia, DrSarjiwan Kaur, Dr. Reetu Goyal
Keywords
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