Antinociceptive and cytotoxic potential of ethanolic extract of Delonix regia (Leaves)
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2014, Vol 2, Issue 1
Abstract
This study investigated the antinociceptive and cytotoxic effects of alcoholic extract of Delonix regia Leaves in rodents. Antinociceptive activities were done using paw licking and writhing tests. The extract was used at dose of 200 and 400 mg/kg per orally as compared to Standard drug Diclofenac-Na 100 mg/kg bw in Swiss albino mice of body weight 25-30 g. The cytotoxic activity was determined by the Brine Shrimp lethality bioassay. The alcoholic extract showed very highly significant effect in formalin test (p<0.01). Also had the highest analgesia (p<0.001) in the acetic acid-induced writhing model as well. The extract possessed a good in vitro cytotoxic activity (LC50=4.06 μg/ml). The results suggested that Delonix regia Leaves extract has a suitable antinociceptive effect as well as cytotoxic potential.
Authors and Affiliations
Rozina Parul| Department of Pharmacy, Gono Bishwabidyalay, Savar, Dhaka-1344, Md. Jahir Alam| Department of Pharmacy Practice, North South University, Bashundhara, Dhaka-1229, Md. Sohel Rana| Department of Pharmacy , Jahangirnagar University, Savar, Dhaka- 1342
Keywords
Related Articles
- EP ID EP14098
- DOI -
- Views 345
- Downloads 19
In-vitro antimicrobial susceptibility testing of bacteria causing diarrhea in children at Khartoum State- Sudan
Background: Diarrhea remains a major public health problem in developing countries. The current study was design to assess the antimicrobial susceptibility testing of bacteria causing diarrhea in children those antibio...
Association of altered serum levels of Chemerin, Paraoxonase-1 (PON1), Asymmetric Dimethyl arginine (ADMA) and obesitin the development of Polycystic Ovarian Syndrome (PCOS) in Egyptian women
Chemerinwas recently added to the adipokine family and was identified in human ovarian follicles and follicular fluid that suggests a direct correlation between chemerin and PCOS. Asymmetric dimethyl arginine (ADMA) is...
Quantitative reckoning of embelin from fruits of Embelia tsjeriam- cottam using water bath process as an alternate method of extraction
The world is culturally endowed with various forms of healing practices having rich medical wisdom of immense importance. One of such pharmacognostically indispensable medicinal plant is Embelia tsjeriam-cottam A. DC....
Effects of green tea and chamomile tea on plaque pH, salivary pH, Streptococcus mutans count
Aim: Green tea is healthy beverage and is a part of our day to day life. Similarly, chamomile tea is known for its aspirin like properties. Beneficial effects of these tea includes protection against dental caries, per...
Sublingual tablets: an overview
Oral administration is one of the most convenient forms for the intake of drug due to ease of administration, painless, versatility, and paramount patient compliance. The demand of fast disintegrating tablets has been gr...