ANTIOXIDANT ACTIVITY AND HEPATOPROTECTIVE POTENTIAL OF BALANITES ROXBURGHII FRUITS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 4
Abstract
ABSTRACTObjectives: The objective of the present study was to evaluate antioxidant activity and hepatoprotective potential of a hydroalcoholic extract ofBalanites roxburghii (BR) fruits.Methods: Extraction was performed by triple maceration using ethanol:water as a solvent. The extracts were vaporated using rotavapor. Thenantioxidant capacities were tested using superoxide, hydroxyl, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Determination of hepatoprotectivemodel was performed by thiocetamide induced liver models.Results: The hydroalcoholic extract of BR fruits produced a dose-dependent percentage inhibition on tested free radicals, i.e., superoxide anion(50% inhibition concentrations [IC50] value 190.50 μg/ml), hydroxyl radical (IC50 value 266.30 μg/ml), and DPPH radical (IC50 value 175 μg/ml). Aftertreatment with silymarin and hydroalcoholic extract of BR in respective groups, they had showed good protection against thioacetamide induced livertoxicity.Conclusion: The results of the present investigation clearly indicate the free radical scavenging activity and hepatoprotective potential of ahydroalcoholic extract of BR fruits and this activity is comparable with that of the standard drugs ascorbic acid and silymarin.Keywords: Balanites roxburghii, Antioxidant activity, Hepatoprotective activity, Ascorbic acid.
Authors and Affiliations
Haritha Polimati, Tadi Rajananda Swamy, Battu Ganga Rao
Keywords
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