Antioxidant activity of Enicostemma axillare L., on fructose induced heart disease in swiss albino rats
Journal Title: International Journal of Allied Medical Sciences and Clinical Research - Year 2016, Vol 4, Issue 2
Abstract
The antioxidant effect of the ethanolic extract of Enicostemma axillare, an indigenous ayurvedic medicinal plant used in India, was studied in rats with fructose-induced cardiac diseases. Rats were divided into four groups: Groups 1 received Normal feed with water. Groups 2 received Fructose treated (The oral administration of 10g of fructose/ 100ml of distilledv water/kg body weight for 21 days), Groups 3 received Fructose and low dose of Enicostemma axillare (150mg/ kg B.wt.)].Groups 4 received Fructose and high dose of Enicostemma axillare treated [oral administration of fructose (10g/ 100ml distilled /kg b. wt) and Enicostemma axillare (250mg/ kg B.wt.)]. For 21 days. The results showed significantly elevated level of serum and tissue thiobarbituric acid reactive substances, and significantly lowered activities/levels of antioxidants such as, catalase, glutathione-S-transferase and reduced glutathione in fructose -treated rats compared with control rats. Administration of ethanolic extract of Enicostemma axillare to rats with fructose -induced liver injury significantly decreased the levels of serum and tissue thiobarbituric acid reactive substances and significantly elevated the activities of catalase, glutathione-S-transferase and reduced glutathione in the tissues compared with unsupplemented fructose -treated rats. These findings suggest that ethanolic extract of Enicostemma axillare has a modulatory effect on fructose -induced hepatotoxicity in rats.
Authors and Affiliations
Dr. J. Jayachitra
Keywords
Related Articles
- EP ID EP419788
- DOI -
- Views 50
- Downloads 0
Nano-Medicine Global Market
Late 19th century was evident of intelligent biomaterial; which has changed researcher’s perspective towards science and technology. This intelligent biomaterial is envisioned to have huge impact on Healthcare from seq...
Immediate effect of mulligan bent leg raise versus neurodynamic sliding on hamstring tightness in non-athletic college students
Background Flexibility is important for normal functioning of humans. Hamstring tightness is a common problem in non- athletic young adults. Hamstrings tightness can further lead to back problems and also can cause hamst...
Effect of pilates on pain and quality of life in females with primary dysmenorrhea
Background and Aim Dysmenorrhea is a gynecological disorder which is characterized by lower abdominal pain which may irradiate to thighs and top and bottom of the spine. Primary dysmenorrhea occurs when there is no ident...
Dentistry on web- Teledentistry
The world has evolved with new technologies and one of the technology is Teledentistry. Teledentistry is a combination of telecommunication and dentistry and involves exchange of clinical information and images over remo...
Efficacy of yoga to improve balance and reduce fall in community dwelling elders who are at risk of fall
Identification of older adults who are at a risk for falling is a vital medical concern. Falls are common events in the lives of older people and can result in a range of adverse outcomes, from minor bruises to fractures...