ANTIOXIDANT ACTIVITY OF SOME NEWLY PREPARED SYMMETRICALLY AZO DYES DERIVED FROM SULFA DRUGS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 2
Abstract
Objective: Sulfa drugs (sulfonamides) were the first type of drugs largely medically used for preventive and chemotherapeutic agents against various types of diseases. To the date, much research has been directed toward the synthesis sulfa drug derivatives such as azo‑sulfa drug compounds. The aim of the present study is to synthesize of azo‑sulfa compounds as antioxidant agents. Methods: First, three of sulfa drugs react with 4‑methoxy‑1,2‑Naphthoquinone in aqueous medium by stirring at room temperature to give symmetrically azo‑sulfa compounds. The colored compounds which formed were examined their structures by infrared and proton nuclear magnetic resonance spectral techniques. Results: Three symmetrically azo‑sulfa compounds were tested as antioxidant agents compared with ascorbic acid (AA) using 2,2‑diphenyl‑1‑picrylhydrazyl method. The results indicated that these compounds had good activities (57.79–73.69%) at 30 μg/ml, which had less activity than AA (81.34%) at the same concentration. These results referred the IC50 which had values (15.23–21.35 μg/ml), whereas AA had 7.59 μg/ml. Conclusion: Attachment of heterocyclic rings containing nitrogen and oxygen (isoxazole) on the azo‑sulfa compounds can enhance the antioxidant activity as compared with the heterocyclic rings containing nitrogen only (pyrimidine) and without heterocyclic rings, which enhanced the lipophilicity which may increase the bioavailability and efficacy of the drug.
Authors and Affiliations
MUNTHER ABDULJALEEL MUHAMMAD‑ALI, HUSSAM HAMZA SALMAN, EKHLASQANBER JASIM
Keywords
Related Articles
- EP ID EP608816
- DOI -
- Views 125
- Downloads 0
SYNTHESIS, BIOLOGICAL EVALUATION, AND DOCKING STUDY OF NOVEL 2-PHENYL-1- BENZOPYRAN-4-ONE DERIVATIVES - AS A POTENT CYCLOOXYGENASE-2 INHIBITOR
Objective: The inflammation and oxidative stress were related together in the generation of reactive oxygen species, which is responsible for the enhancement of inflammation associated with various chronic diseases. Met...
ANTIMICROBIAL ACTIVITIES OF SUCCESSIVE SOLVENT EXTRACTS OF ALBIZIA LEBBECK AND SOLANUM SEAFORTHIANUM AGAINST SOME HUMAN PATHOGENIC MICROORGANISMS
Objective: The continuous emergence of multidrug resistance bacteria and yeast, and the negative impact of synthetic preservatives have led to an increased interest in the use of plant extracts as alternative antimicrobi...
STUDY ON APHRODISIAC ACTIVITY OF OLEA DIOICA ROXB. BARK, LEAF EXTRACTS, AND ITS PURE COMPOUND USING WISTAR ALBINO RATS
Objectives: We aimed to assess the effects of O. dioica Roxb. leaf and bark extract and its isolated constituent benzeneethanol, 4-hydroxy- on aphrodisiac activity in rats using different standard aphrodisiac parameters....
PHARMACOLOGICAL EVALUATION OF ANTINEOPLASTIC ACTIVITY OF HYDROETHANOLIC EXTRACT OF UNRIPE FRUIT OF CARICA PAPAYA LINN USING ANIMAL MODEL
Objective: This study was undertaken to screen the effect of administration of various doses of hydroethanolic extract of unripe fruit of Carica papaya L. (HEECP) against Dalton’s ascitic lymphoma (DAL) in Swiss albino...
DEVELOPMENT AND EVALUATION OF FLOATING TABLET OF METOPROLOL SUCCINATE FOR INCREASED BIOAVAILABILITY VIA IN VIVO STUDY
Objective: This study was performed to formulate a floating tablet using hydrophobic glyceryl behenate (GB) and hydrophilic hydroxypropyl methylcellulose polymers, optimization of the same for retention in stomach and su...