ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF BIOACTIVE EXTRACTS OF A POLYPORE MUSHROOM, FOMITOPSIS PINICOLA (SW.:FR.) P. KARST, FROM KASHMIR.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 8
Abstract
Fomitopsis pinicola, a polypore mushroom, was investigated for its medicinal properties. In this study, antioxidant and anti-inflammatory activities of the mushroom were examined. The fruiting bodies of the mushroom were defatted with petroleum ether, and then extracted with ethyl acetate (EA) and ethanol (ETH). Both the extracts were found to possess radical scavenging activities against DPPH., ABTS.+, nitric oxide and OH. radicals. The extracts also reduced Fe3+ ions and inhibited lipid peroxidation. The extracts were further evaluated for their anti-inflammatory activity against carrageenan and formalin induced acute and chronic edema respectively in mouse model. An oral dose of 500 mg/Kg body weight of EA extract inhibited both acute and chronic inflammation by 52.77 and 46.44% and the ETH extract at the same dose inhibited 33.33 and 30.44% respectively. EA extract also inhibited carrageenan induced leukocyte infiltration in to the peritoneal cavity of mice. Both EA and ETH extracts lowered ethanol induced liver lipid peroxidation in mice nearly by 60%. Anti-inflammatory activity against croton oil induced skin inflammation showed that topical application of 20 mg of EA reduced skin inflammation and leukocyte infiltration. The extract also lowered lipid peroxidation resulted from croton oil application by almost 60%. In Cylooxygenase (COX) activity assay, EA extract inhibited the activity by 55.85%. Major chemical constituents of the mushroom are steroids, alkaloids, coumarins, phenols, tannins, saponins and carbohydrates. The study thus demonstrated that EA and ETH extracts of F. pinicola possessed significant antioxidant and anti-inflammatory activities.
Authors and Affiliations
Korattuvalappil Sankaranarayanan Ravikumar, Thekkuttuparambil Ananthanarayanan Ajith, Khurshid Iqbal Andrabi.
Keywords
Related Articles
- EP ID EP396902
- DOI 10.21474/IJAR01/7624
- Views 35
- Downloads 0
PERCUTANEOUS BALLOON VALVULOPLASTY FOR BIOPROSTHETIC TRICUSPID VALVE STENOSIS.
Percutaneous Balloon Valvuloplasty for Bioprosthetic Tricuspid Valve Stenosis (PBVBTV) is an accepted therapeutic option for symptomatic severe bioprothetic tricuspid valve stenosis, whereas a surgical tricuspid valve re...
DESIGN AND MATHEMATICAL MODELING OF SPRAY DRYER USING CFD.
This paper presents the prediction of air flow, temperature patterns and mass fraction of water vapour in a co-current spray dryer fitted with rotary disc atomizer. The multiphase CFD model was developed in which the gas...
PREVALENCE OF HEPATITIS B AND C VIRUS ANTIBODIES AMONG STUDENTS INVOLVED IN RISKY SEXUAL BEHAVIOR IN A NIGERIAN TERTIARY INSTITUTION.
Sexual contact is one of the ways hepatitis B and C can be transmitted. Limited investigations have been recorded on the prevalence of HBV and HCV antibodies among students involved in risky sexual behavior in tertiary i...
THE IMPACT OF HEALTH-RELATED PROBLEM ON ACADEMIC ACHIEVEMENT OF STUDENTS: APPLICATION OF DUMMY VARIABLE REGRESSION MODEL
Health is a base for social, cultural and economic development of society. But sometimes attaining this health, unfavorable condition is impossible due to some health problems. The aim of this study is to identify the ma...
CLINICAL STUDY OF ASSOCIATION BETWEEN THE SERUM SODIUM LEVEL AND SEVERITY OF COMPLICATIONS IN LIVER CIRRHOSIS AT KANYAKUMARI GOVERNMENT MEDICAL COLLEGE.
Background: Cirrhosis is defined histopathologically and has variety of clinical manifestations and complications, some of which can be life-threatening..Dilutionalhyponatremia associated with liver cirrhosis is caused b...