Antioxidant and Antibacterial compounds from the leaves of Psidium guajava

Journal Title: World Journal of Pharmaceutical Sciences - Year 2017, Vol 5, Issue 11


Psidium guajava Linn., family Myrtaceae, commonly known as guava, is an important food crop and medicinal plant in tropical and subtropical countries. Previous studies reported major contribution of the ethyl acetate fraction of P. guajava leaf extract to possess antioxidant and antibacterial activities. Therefore, the ethyl acetate fraction of P. guajava was subjected to chromatographic separation to explore the bioactive molecules responsible for these activities. Five known compounds were isolated and characterized using physical, chemical and spectral analysis. Quercetin-3-O-β-arabinopyranoside was isolated for the first time from this plant. Alongside this compound, the other four compounds viz., pyrogallol, quercetin, quercetin-3-O-β-D-xylopyranoside (reynoutrin) and quercetin-3-O-α-L-arabinofuranoside (avicularin) exhibited an exceptional antioxidant activity using ABTS●+ assay. The isolated pure compounds were further investigated for their antibacterial activity against both Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) bacteria. Pyrogallol didn't display any significant antibacterial activity against both types while, quercetin showed remarkable activity compared to ampicillin as a positive control assuming a promising antibacterial drug. Moreover, the three quercetin glycosides exhibited moderate antibacterial activity when compared to ampicillin.

Authors and Affiliations

Prof. Farid A. Badria


Related Articles

Evaluation of in vitro antidiabetic activity of red seaweed Portieria hornemannii (Lyngbye) (Silva) and Spyridia fusiformis (Wulfen)

In the present study in vitro antidiabetic activity of red seaweed Portieria hornemannii (Lyngbye) (Silva) and Spyridia fusiformis (Wulfen) were evaluated using α-amylase and α-glucosidase for inhibitory activity. The me...

Screening and sensitivity of candida isolates from women affected with urinary tract infections at Perambalur, Tamilnadu, India

This investigation enrolled 75 clinical specimens collected from women with Urinary Tract Infections (UTI) at Perambalur, Tamilnadu, India. Among the 75 samples analysed, 42 were positive for Candida. The candida isolate...

Formulation and evaluation of amlodipine besylate elementary osmotic tablets

The present work was aimed to formulate and evaluate osmotic pump delivery system of Amlodipine Besylate using two osmogens (NaCl and KCl) by wet granulation method. The osmogens used in this study did not alter the phys...

Novel electrochemical quantification for nepafenac in raw drug, pharmaceutical eye drops and biological fluid

This article pronounces differential pulse voltammetric technique for the determination of nepafenac in pharmaceutical dosage form and human serum. The proposed voltammetric technique was established on electro-oxidation...

Optimization of Microwave Assisted Extraction of Total Phenolic Contents from Triticum aestivum L. Whole-grain Cereal

Whole-grain cereals have unique blend of bioactive constituents and antioxidants which are proposed to be responsible for the health profits of whole-grain consumption. Nevertheless, phytochemicals and antioxidants in wh...

Download PDF file
  • EP ID EP331163
  • DOI -
  • Views 30
  • Downloads 0

How To Cite

Prof. Farid A. Badria (2017). Antioxidant and Antibacterial compounds from the leaves of Psidium guajava. World Journal of Pharmaceutical Sciences, 5(11), 56-63.