ANTIOXIDANT AND ANTIINFLAMMATORY EFFECTS OF VITEX NEGUNDO ON FREUND’S COMPLETE ADJUVANT INDUCED ARTHRITIS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 1
Abstract
Objective: Vitex negundo, commonly known as “nirgundi†is widely used in traditional as well as in folk medicines to cure many ailments such as fever, rheumatism, gum and skin diseases and liver disorders, etc. The present study evaluated the antioxidant potency of hydroethanolic extract of Vitex negundo leaves (VNE) in Freund’s complete adjuvant (FCA) induced arthritis.Methods: Acute oral toxicity test of VNE at various increasing doses and its effect on biochemical markers of hepatotoxicity and renal toxicity along with histopathology were studied. The experimental arthritis was induced by subcutaneous injection of FCA at the right hind paw of male albino rats. Treatment with indomethacin (10 mg/kg body weight) and VNE (200 mg/kg body weight) was given to arthritic rats to study the effects on liver and erythrocytes malondialdehyde (MDA) and antioxidant status. Anti-inflammatory activities were studied by inhibition in paw edema.Results: The results showed that the use of VNE, up to the dose of 5 g/kg body weight was nontoxic. Oral administration of VNE significantly modulated antioxidant status and reduced MDA content. VNE also exhibited anti-inflammatory activity shown by inhibition in paw edema of arthritic rats.Conclusion: Vitex negundo leaves possess potent antioxidant and anti-inflammatory activity by modulating the oxidant/antioxidant in favor of reducing oxidative stress and thereby; the inflammation in FCA induced RA.Â
Authors and Affiliations
Harsha Lad, Deepti Dixit, Ankita Joshi, Deepak Bhatnagar
Keywords
Related Articles
- EP ID EP579161
- DOI -
- Views 101
- Downloads 0
PHARMACOKINETIC STUDIES OF NEW SILVER-BASED COMPLEX
Objective: Investigation of pharmacokinetics parameters of the new silver-based compound of general formula C6H19Ag2N4LiO6S2, called “Argosilâ€, with high antiviral activity.Methods: Water solution of complex administ...
OBSERVATIONAL STUDY ON POISON CASES IN A TERTIARY CARE HOSPITAL
Objective: To evaluate the prevalence, pattern, and cause of poisoning. To characterize the poisoning cases admitted in a tertiary care hospital; followed by the outcome and to observe the antidote given for the poison c...
AZATHIOPRINE INDUCED PANCYTOPENIA-A CASE REPORT
Azathioprine (AZA), a prodrug of 6 mercaptopurine, is an immunosuppressant that can be used as adjunctive therapy with corticosteroids in the treatment of arteritic form of ischemic optic neuropathy. Although myelotoxici...
FORMULATION AND EVALUATION OF ORAL SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM OF CANDESARTAN CILEXETIL
Objective: The objective of our investigation was to formulate a liquid self micro emulsifying drug delivery system (SMEDDS) of candesartan cilexetil that could improve its solubility, stability, and oral bioavailability...
REVIEW ON ANTIHYPERLIPEDEMIA LIPOPHILIC DRUGS AND THEIR NOVEL FORMULATION APPROACHES
It has been ranked as one of the greatest risk factors contributing to prevalence and severity of coronary heart diseases (CHD). CHD, stroke, atherosclerosis and hyperlipidemia are the primary cause of death. The increas...