ANTIOXIDANT AND ANTIULCER POTENTIAL OF ETHANOLIC EXTRACT OF BARK OF MYRICA ESCULENTA IN PYLORIC LIGATION ULCER MODEL
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: To evaluate the antiulcer and antioxidant potential of ethanolic extract of bark of Myrica esculenta in pyloric ligated ulcer model in albino rats.Methods: The rats were subjected to pyloric ligation ulcer model and the ethanolic extract of bark of Myrica esculenta were compared with the induced and standard drug Ranitidine. The activity of antioxidant parameters was analysed in the homogenate of stomachs.Results: The levels of gastric volume, total acidity, free acidity, lipid peroxidation and glutathione (GSH) were reduced significantly and antioxidant, parameters like catalase, nitrite and myeloperoxidase (MPO) were increased significantly in the ethanloic extract of bark of Myrica esculenta. Conclusion: The present study revealed that the ethanolic extract of bark of Myrica esculenta improved the anti ulcer and antioxidant potential. Â
Authors and Affiliations
Dharma Swathi, K. V. S. R. G. Prasad
Keywords
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