ANTIOXIDANT AND HEPATO PROTECTIVE ACTIVITY OF VARIOUS EXTRACTS OF INDIGOFERA BARBERI GAMBLE AGAINST D-GALACTOSAMINE INDUCED TOXICITY IN RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 10
Abstract
Objective: To investigate Antioxidant and Hepatoprotective activity of various extracts of Indigofera barberi Gamble against D-Galactosamine induced toxicity in rats.Methods: Indigofera barberi Gamble is used traditionally as folk system of medicine in India for the treatment of liver diseases, and as a liver tonic. Petroleum ether (PEEIB), chloroform(CEIB) and ethanolic extracts (EEIB) of Indigofera barberi Gamble (aerial part of the plants extracts, 200mg/kg, p. o) was tested for its hepatoprotective effect against D-galactosamine induced hepatic damage in rats at a dose of (400mg/kg, i. p) to induce hepatotoxicity and Silymarin (25 mg/kg, i. p.) was administered as standard drug.Results: The biochemical parameters of liver tissue LPO, GSH, GPX, GST, SOD and CAT values were significantly (p<0.01) altered against ethanolic extracts treatment of Indigofera barberi Gamble and were comparable with standard drug silymarin. Conclusion: Animal pretreatment with petroleum ether and chloroform extracts of Indigofera barberi Gamble did not change above mentioned parameters significantly. The histopathological studies also substantiates the results and hence, it can be concluded from the present study that, the ethanolic extracts of Indigofera barberi Gamble has appreciable hepatoprotective potential in albino rats against D-galactosamine induced hepatic damage.Â
Authors and Affiliations
N Srinivasan, Sathyanarayana. D
Keywords
Related Articles
- EP ID EP579409
- DOI -
- Views 66
- Downloads 0
MOLECULAR CHARACTERIZATION OF ENDANGERED MEDICINAL PLANT SPECIES HEDYCHIUM CORONARIUM FROM EASTERN INDIA
Objective: Molecular characterization of Hedychium coronarium from 4 different populations of Odisha using 9 inter simple sequence repeats and 15 random amplified polymorphic DNA markers to indicate the closeness of spec...
EXTRACTS OF EUPHOBIA HIRTA LINN AND PHYSALIS ANGULATA L. AND THEIR AMALGAMATION DEMONSTRATE POTENCY AGAINST STAPHYLOCOCCUS AUREUS AND PSEUDOMONAS AERUGINOSA
Objective: The goal was to investigate the antibacterial activity of the extracts of Euphobia hirta and Pysalis angulata from Ghana on clinical bacteria isolate found to associate with wound and skin infections.Methods:...
FORMULATION AND IN VITRO EVALUATION OF AZILSARTAN MEDOXOMIL NANOSUSPENSION
Objective: The objective of this study was to formulate and evaluate of the poorly soluble drug, azilsartan medoxomil into nanosuspension to increase the solubility and enhance the dissolution rate and then improve its b...
A COMPARATIVE STUDY ON THE EFFECT OF SOLVENTS ON THE PHYTOCHEMICAL PROFILE AND BIOLOGICAL POTENTIAL OF ORMOCARPUM COCHINCHINENSE AUCT. NON (LOUR.) MERRILL
Objective: Plants contain different classes of phytochemicals which have different levels of solubility in solvents, based on their polarity. Hence, this study aims to compare the effects of various solvents on the phyto...
IN SILICO PROBING OF ANTI-ARTHRITIC POTENTIAL OF TRADITIONALLY FERMENTED AYURVEDIC POLYHERBAL PRODUCT BALARISHTA REVEALS LUPEOL AND DESULPHOSINIGRIN AS EFFICIENT INTERACTING COMPONENTS WITH UREC
Objective: To assess the anti-arthritic properties of Balarishta, an Ayurvedic fermented poly herbal product used to combat the immunological disorder, Rheumatoid Arthritis which is an autoimmune disease triggered by Pro...