ANTIOXIDANT AND HEPATO PROTECTIVE ACTIVITY OF VARIOUS EXTRACTS OF INDIGOFERA BARBERI GAMBLE AGAINST D-GALACTOSAMINE INDUCED TOXICITY IN RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 10
Abstract
Objective: To investigate Antioxidant and Hepatoprotective activity of various extracts of Indigofera barberi Gamble against D-Galactosamine induced toxicity in rats.Methods: Indigofera barberi Gamble is used traditionally as folk system of medicine in India for the treatment of liver diseases, and as a liver tonic. Petroleum ether (PEEIB), chloroform(CEIB) and ethanolic extracts (EEIB) of Indigofera barberi Gamble (aerial part of the plants extracts, 200mg/kg, p. o) was tested for its hepatoprotective effect against D-galactosamine induced hepatic damage in rats at a dose of (400mg/kg, i. p) to induce hepatotoxicity and Silymarin (25 mg/kg, i. p.) was administered as standard drug.Results: The biochemical parameters of liver tissue LPO, GSH, GPX, GST, SOD and CAT values were significantly (p<0.01) altered against ethanolic extracts treatment of Indigofera barberi Gamble and were comparable with standard drug silymarin. Conclusion: Animal pretreatment with petroleum ether and chloroform extracts of Indigofera barberi Gamble did not change above mentioned parameters significantly. The histopathological studies also substantiates the results and hence, it can be concluded from the present study that, the ethanolic extracts of Indigofera barberi Gamble has appreciable hepatoprotective potential in albino rats against D-galactosamine induced hepatic damage.Â
Authors and Affiliations
N Srinivasan, Sathyanarayana. D
Keywords
Related Articles
- EP ID EP579409
- DOI -
- Views 46
- Downloads 0
EXTRACTION AND CHARACTERIZATION OF GELATIN: A FUNCTIONAL BIOPOLYMER
Objective: Gelatin is widely used biopolymer in various industries due to its excellent biocompatibility, biodegradability properties. In the present study, gelatin was extracted from fish wastes, as an alternative sourc...
COMPARATIVE STUDIES OF ANTIOXIDANT ACTIVITY FROM THE PETALS OF SELECTED INDIAN MEDICINAL PLANTS
Objective: The present study was to evaluate the in vitro antioxidant activity from the petals of four different Indian medicinal plants (Punica granatum, Hibiscus rosasinensis, Cassia auriculata and Moringa oleifera).Me...
GENOTOXIC AND MUTAGENIC STUDIES OF THE ANTIEPILEPTIC DRUG LEVETIRACETAM IN PREGNANT RATS AND THEIR FETUSES
Objective: Levetiracetam (LEV) is an anti-epileptic drug, initially approved as an adjunct therapy in adult patients with partial-onset seizures, and used as monotherapy treatment during pregnancy. However, very few, if...
IN VITRO ANTIBACTERIAL ACTIVITIES OF MARINE SPONGE-ASSOCIATED BACTERIA AGAINST PATHOGENIC VIBRIO SPP. CAUSES VIBRIOSIS IN SHRIMPS
Objective: This study was aimed to isolate and screen marine sponge-associated bacteria producing anti-Vibrio compounds and to identify their compounds from the bacterial extract. Methods: Sponge-associated bacteria wer...
COMPARATIVE STUDY ON THE EFFICACY OF MOMETASONE AND FLUTICASONE NASAL SPRAYS FOR TREATMENT OF ALLERGIC RHINITIS
Objective: Allergic rhinitis is the most prevalent of allergic diseases in the world. Nasal corticosteroids are the most applicable drugs for the treatment of allergic rhinitis. In this study, we compared the efficacy of...