Antioxidant and in vitro cytotoxic activity of extracts of aerial parts of Cocculus hirsutus (L) using cell line cultures (breast cell line)
Journal Title: The Journal of Phytopharmacology - Year 2014, Vol 3, Issue 6
Abstract
The aim of the present study was to evaluate the in vitro cytotoxic activity of methanolic and aqueous extract of aerial parts of Cocculus hirsutus on MCF-7 breast cell lines. Qualitative phytochemical screening tests were performed to detect phytochemicals in the extracts. Antioxidant activity of the plant extracts were characterized by using DPPH free radical scavenging method. The cytotoxic activity of the extracts of Cocculus hirsutus on MCF-7 cells was investigated in vitro through MTT assay. The results showed Antioxidant activity using DPPH were found to be increased in a concentration dependent manner and decreased cell viability and cell growth inhibition in a dose dependent manner. The findings from this study indicated that methanolic and aqueous extracts of Cocculus hirsutus leaf possessed vast potential as a medicinal drug especially in breast cancer treatment.
Authors and Affiliations
Khushbu N. Thakkar, A K Prasad, Jyotiranjan Nayak, Satish V. Iyer, Shankul kumar
Keywords
Related Articles
- EP ID EP49590
- DOI -
- Views 227
- Downloads 0
In silico documentation of medicinal plants in Lacchiwala range, Dehradun forest division, Uttarakhand (India)
The Himalaya is the treasure house of natural wealth, particularly of medicinal plants. The drugs from different plant species have been known to the Indian physician since long - long ago. A number of important herbal...
Ethnomedicinal documentation of antimicrobial plants from south east Rajasthan, India
South east Rajasthan houses diversified tribes belonging to primitive or aboriginal culture which inherit good deal of therapeutic information from herbal resources. Survey of ethnic localities reveals usage of plants f...
Experimental study on Operculina turpethum in STZ induced diabetic neuropathy, neurodegeneration and cardiovascular complications
Neuropathy and Cardiac complications are the most common trouble in diabetes mellitus with progressive damage due to complex pathogenesis. Many conventional pharmacological agents were withdrawn from clinical studies e...
A review on Ficus palmata (Wild Himalayan Fig)
Traditionally, various plants are used for treatment of many diseases. Ficus palmata is a herbaceous perennial plant belonging to the family Moraceae. It contains a very juicy fruit and is used for making various produ...
Isolation of Daphnetin 8-methyl ether from Daphne oleoides and its Anti-bacterial activity
The aim of the present work was to isolate and identify secondary metabolites of Daphne oleoides, which was not phytochemically analysed in this important geographical region of the world until now, followed by the det...