Antioxidant and Radical Scavenging Properties of β-Carotene on Cisplatin Induced Cardiotoxicity
Journal Title: Cardiology and Angiology: An International Journal - Year 2015, Vol 4, Issue 3
Abstract
Objective: To investigate the protective role of β-Carotene against cisplatin induced cardiotoxicity in male albino rats. Methods: Various biochemical parameters such as Creatine kinase-MB, Lactate dehydrogenase (LDH), Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Triglycerides (TG) and Total cholesterol (TC) are being assessed. Also the levels of the in vivo antioxidants such as Reduced glutathione (GSH), Catalase (CAT), and Malondialdehyde (MDA) in the post mitochondrial supernatant of heart were measured. In addition, the histopathological studies were performed to study the protective activity of β-carotene. Results: Cisplatin administration has shown the elevated levels of the cardiac markers and diminished the endogenous antioxidant levels when compared with the normal rats. β-carotene treatment showed the inhibitory effect on the free radicals showing decreased levels of the cardiac markers like CK-MB, LDH, AST, ALT and ALP. The β-carotene treated rats showed significant (p<0.001) decrease in lipid peroxidation in both prophylactic and curative groups when compared to the cisplatin group. Also showed a significant (p<0.05, p<0.001) increase in the levels of GSH in prophylactic and curative group respectively when compared with the cisplatin group. Both prophylactic and curative groups have shown a significant (p<0.001) increase in the levels of CAT. Further, the histopathological studies confirm the protective effect of β-carotene. Conclusion: These findings justify the biological and traditional uses of β-carotene as confirmed by its promising radical scavenging activity against cisplatin induced cardiotoxicity.
Authors and Affiliations
B. Uday Kiran, M. Sushma, K. V. S. R. G. Prasad, V. Uma Maheshwara Rao, D. Jhansi Laxmi Bai, V. Nisheetha
Glutathione: Glutathione Sulfide Redox Imbalance in Early Impaired Fasting Glucose
Aim: The current study aims to examine the balance between glutathione and glutathione sulfide and how this was disturbed in patients with impaired fasting glucose (IFG) level. The study also included 8-hydroxy-2’-deoxyg...
Assessment of the effect of Watermelon and Aloe Vera on Cadmium Induced Heart Damage in Adult Wistar Rats (Rattus novergicus)
The aim of the study was to investigate the antioxidant property of watermelon and aloe vera against cadmium damaging effect on the heart and the packed cell volume of the blood. Thirty five Wistar rats were obtained and...
Serum Zinc Levels do not Differ in Type 2 Diabetic Subjects with and without Coronary Artery Disease
Aims: The scope of this study is to investigate zinc levels in type 2 diabetic subjects with and without coronary artery disease (CAD). Place and Duration of Study: This study was performed in outpatient clinic of Gener...
Imaging of Congenital Subclavian Artery to Subclavian Vein Fistula in a Newborn
The purpose of this paper is to report a congenital subclavian artery to subclavian vein fistula in a three weeks old male infant who presented with congestive heart failure and pulmonary hypertension. He had been scanne...
Comparison of Cardiovascular Risk in Microalbuminuric and Normoalbuminuric Type 2 Diabetic Patients in Nigeria
Aim: To compare cardiovascular risk in microalbuminuric and normoalbuminuric type 2 diabetic patients. Study Design: Cross-sectional study. Methodology: Blood pressure, body mass index (BMI), electrolytes, fasting plasma...