Antioxidant Effects of Green-Tea on biochemical and Histopathological Changes of liver in Male Rats Poisoned by Malathion Insecticide
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 5
Abstract
Malathion is an organophosphate pesticide which is widely used in agriculture, veterinary and industries. Oxidative stress has been identified as one of Malathion’s main molecular mechanisms of action in plasma, liver, pancreas, muscles and the brain. Green tea (Camellia sinensis), which is the most common drink across the world after water, has many antioxidant properties. The purpose of this research is to investigate the effects of Malathion on the liver and the preventive effects of green tea on Malathion-induced poisoning. Seventy-two Wistar male rats were randomly divided into the control, the sham, and the experimental groups (receiving respectively 40 mg/kg of Malathion; 100, 200, and 400 mg/kg of green tea; and 100, 200, and 400 mg/kg of Malathion and green tea respectively). All injections were performed intraperitoneally for 14 consecutive days. On the 15th day, blood samples were taken from the hearts of the rats to measure serum level of hepatic enzymes, and their liver tissues were removed to be studied. To do the statistical analysis One-way ANOVA test and Duncan’s test at the 5% significance level were used. aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), Malondialdehyde (MDA) and Total Oxidation Capacity(TOC) concentrations in the treatment groups with Malathion and green tea extract at 100, 200, and 400 mg/kg doses showed a significant decline compared to the Malathion group(p<0.05), whileTotal Antioxidant Capacity (TAC) level showed a significant increase with various doses of green tea and Malathion compared to the Malathion group (p<0.05). Green tea, probably due to its strong antioxidant properties, could improve the destructive effects of Malathion on the rat liver.
Authors and Affiliations
Rahim Raoofi| Department of Infection Diseases, Faculty Member of Medicine, Jahrom University of Medical Science,Jahrom, Iran, Hossein Kargar Jahromi| Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iranو Corresponding Email: hossein.kargarjahromy@yahoo.com, Zahra Kargar Jahromi| Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran, Hassan Ali Abedi| Department of Physiology, Jahrom University of Medical Sceices, Jahrom, Iran, Hadi Sameni| Research Center for Noncommunicable Diseases, Faculty of Medicine,Jahrom University of Medical Sciences, Jahrom, Iran, Morteza Pourahmad| Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iranو Research Center for Noncommunicable Diseases, Faculty of Medicine,Jahrom University of Medical Sciences, Jahrom, Iranو Infectious diseases and tropical medicine research center, Isfahan University of medical sciences, Isfahan, IR Iran
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