ANTIOXIDANT EFFECTS OF LOVASTATIN ON COPPER-MEDIATED IN-VITRO OXIDATIVE MODIFICATION OF LDL IN INFLAMMATION INDUCED HYPERLIPIDEMIA IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
Cardiovascular diseases (CVD) are the main cause of disability and premature dead worldwide. Epidemiological studies have suggested a link between atherosclerosis and inflammation. Atherosclerosis is a multifaceted diseases process with several different well defined risks factors, such as hypercholesterolemia, hypertension and diabetes. The present study was carried out to investigate the efficacy of antioxidant agent lovastatin. The study comprises the antioxidant status of Lovastatin by analyzing all the parameters in plasma, TL, TC, TG, VLDL-C, LDL-C, non-HDL-C, MDA and in-vitro oxidizability of LDL in absence or presence of Lovastatin. All the plasma lipids parameters, TL, TC, TG, VLDL-C, LDL-C, non-HDL-C and MDA levels were significantly increased in inflammation induced hyperlipidemic (IIH-C) rats. After 4-weeks administration of Lovastatin (1mg/ml) to IIH-C rats were useful in the prevention and treatment of inflammation induced hyperlipidemia, CVD and atherosclerosis. Lovastatin significantly reduced the overall oxidative burden and effectively ameliorated the above altered parameters.
Authors and Affiliations
Amir Khan, Jawed Shozab , Mahesha Nand, Lakhvinder Singh, Rishab Jain , Munish Thakur
Keywords
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