Antioxidant Efficacy of Black Tea and Green Tea Equally Modulates Vasculogenic Factors in Preeclamptic Placental Trophoblast: A Comparative Study
Journal Title: International Journal of Current Research and Review - Year 2018, Vol 10, Issue 11
Abstract
Aim: Preeclampsia is hypertensive disorder of human pregnancy. Trophoblast, a prime cell of the placenta, is affected during preeclampsia due to the imbalance between oxidant and antioxidants resulting in aberrant cellular vascularization. Vasculogenesis is regulated by the endothelial nitric oxide synthase (eNOS), a potent vasodilator, regulating the expression of growth factors. Vascular endothelial growth factor (VEGF) is a prime regulator of vasculogenesis. Placental growth factor (PLGF) plays a crucial role in placental development during pregnancy. Synthetic drugs can hardly be used under complicated pregnancy. The requirement for herbal remedies renders essential regulatory mechanism to ensure adequate protection from preeclampsia. Methodology: In the current study, black tea and green tea were used to assess the stress markers (LPO and TAC) and vasculogenic factors (ADMA, eNOS, VEGF-C, and PLGF) in normotensive and preeclamptic placental trophoblast. Results: The increased expression of LPO, ADMA and decreased TAC, eNOS, VEGF-C, PLGF were observed in preeclamptic placental trophoblast. On tea incubation, vasculogenic proteins were significantly altered in preeclamptic placental trophoblast when compared with their respective subjects. Discussion: Our present study results reveal that protective effect of black tea is equal to the green tea. This may be due to the tea polyphenols produces a beneficiary effect in the case of the preeclamptic placenta. Conclusion: The present study concludes that tea with or without fermentation process has a significant impact on crucial vasculogenic factors. This effect can be suitably exploited to avoid further complications in preeclamptic pregnancy. .
Authors and Affiliations
Padmini Ekambaram
Keywords
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- EP ID EP542360
- DOI 10.31782/IJCRR.2018.10113
- Views 116
- Downloads 0
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