Abstract

Objective: Free radicals in cigarette smoking may increase oxidative damage and may decreased the antioxidant defense mechanism. Carbonmonoxide also bounds to haemoglobine in erythrocytes, and may hold down capillary blood oxygen saturation (COS) and lactic acid (LA). This study was carried out to investigate the activities of SOD, GSPx, and GSRx enzymes, and the values of COS and LA in children with pneumonia exposed to passive smoking. Materials and Methods: The investigation was performed on 120 children in four groups. The first group was healthy controls; the second was exposed to passive smoking, the third was children with pneumonia and the fourth was exposed to passive smoking with pneumonia. The activities of SOD, GSPx and GSRx enzymes, and the values of capillary oxygen saturation and lactic acid concentretion were determined in all groups. Results: While COS-values were statistically decreased (p<0.05, p<0.01) with PS and PSP; LA-values were significantly increased (p<0.05-p<0.05) in the same groups. In addition, SOD activity by PS (p<0.01), GSPx activities by P and PSP (p<0.05, p<0.05), GSRx activity by P (p<0.05) were significantly decreased. Conclusion: While passive cigarette smoking and passive smoking plus pneumonia were decreased the COS, the values of lactic acid were increased in the same groups. The activities of SOD, GSPx and GSRx were affected with passive smoking and passive smoking plus pneumonia and antioxidant defense mechanism decreased with passive cigarette smoking and passive smoking plus pneumonia.

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