ANTIOXIDANT POTENTIAL AND ANTIMICROBIAL SCREENING OF SOME NOVEL IMIDAZOLE DERIVATIVES
Journal Title: Journal of Biological and Scientific Opinion - Year 2013, Vol 1, Issue 3
Abstract
Bioactive novel imidazole derivatives have been synthesized under solvent free condition using molecular iodine as the catalyst and they are characterized by NMR spectra, X-ray, mass and CHN analysis. Their antioxidant potential were evaluated using different in vitro antioxidant models namely, DPPH (1,1-diphenyl-2-picryl hydroxyl) radical, superoxide anion and hydroxyl radical scavenging activities. The p-tolyl ring at C-3 and p-fluorophenyl at C-2 of the imidazole ring has maximum OH• (fpdmti) when compared with other imidazole derivatives. The low IC50 value may be due to the electron donating (+I effect) ability exerted by the methyl substituent and electron withdrawing (-I effect) ability exerted by the fluoro substituent. The 3,5-dimethylphenyl ring at C-2 of the imidazole ring (dmmppi) has maximum DPPH• and superoxide anion radical scavenging activities when compared with other imidazole derivatives and the low IC50 value of dmmppi) may be due to the electron donating (+I effect) ability exerted by the two methyl substituent’s. Their antibacterial screening against Staphylococcus aureus, Escherichia coli and Klbesiella pneumoniae and antifungal activity against Aspergillus Niger, Aspergillus flavus and Candida-6 were also evaluated.
Authors and Affiliations
N. Srinivasan
Keywords
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- EP ID EP151785
- DOI 10.7897/2321–6328.01305
- Views 110
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