Antiparasitic activity of Alstonia boonei De Wild. (Apocynaceae) against Toxoplasma gondii along with its cellular and acute toxicity
Journal Title: Journal of Research in Biology - Year 2018, Vol 8, Issue 7
Abstract
Toxoplasmosis (Toxoplasma) and malaria (Plasmodium) are two disease caused by parasites of the phylum Apicomplex. The treatment of toxoplasmosis is similar to that of malaria. Traditionally, Alstonia boonei De Willd. (Apocynaceae) is a plant widely used in the treatment of malaria. This study was conducted to assess the antiparasite activity of the 70% hydroethanolic extract of A. boonei on Toxoplasma gondii and to study its cellular and acute toxicity. The in vitro parasitic and cytotoxic assays were performed on HFF cells while the acute in vivo toxicity was performed on (Swiss) mice. The ethanolic extract stopped the proliferation of T. gondii with an IC50 of 0.13 mg/mL. This extract is neither toxic to HFF cells nor to mice at doses lower than 15000 mg/kg/Vo bw. No signs of behavioural toxicity were observed at this same dose. This confirms the traditional use and its safety in the treatment of phylum apicomplex parasites
Authors and Affiliations
Djeneb Camara, Kouadio Bene, Kiyinlma Coulibaly, Yao Kanga, Guédé Noël Zirihi
Keywords
Related Articles
- EP ID EP569648
- DOI -
- Views 55
- Downloads 0
A Study On Uropathogens In Diabetic Patients from a tertiary care Hospital in Kanchipuram
Diabetes has long been one of the predisposing factors of UTI. There were several studies about the role of DM in etiology and resistance pattern of uropathogens with UTI. Hence this study was aimed to know the prevalenc...
Bioremediation of oil contaminated soil using biosurfactant produced by Pseudomonas aeruginosa
Biosurfactants are surfactants that are biologically produced from bacteria, yeasts and fungi. Examples include Pseudomonas aeruginosa which produce biosurfactants from various substrates including sugars, oil and wastes...
Effect of prebiotic (GroBiotic®-A) on the growth performance and intestinal microflora on rainbow trout (Oncorhynchus mykiss Walbaum)
The use of prebiotics as feed supplements that improve efficiency of intestinal bacteria is becoming de rigueur in animal husbandry in many regions worldwide. We tested the effects of a commercial prebiotic (GroBiotic®-A...
Habitat diversity, Morphological and systematic analysis of multipotential species of Aloe barbadensis Mill. (Liliaceae) from the Southern Western Ghats of Tamil Nadu, India
The present paper highlights the habitat variability, morphological features, systematic analysis and multi potentiality of Aloe barbadensis Mill. were collected from Nilgiri district of Southern Western Ghats of Tamil N...
Survey of nature and extent of damage caused by bird pest to pearl millet crop in Patan District (North Gujarat)
Pearl millet is the main crop of Patan district of Gujarat state. It is grown in two seasons viz. kharif and summer. This research was conducted during 2005 and 2006 at Hansapur village of Patan district. Two varieties v...