Antiphosphatidyl Serine Autoantibodies and Premature Coronary Events
Journal Title: Sultan Qaboos University Medical Journal - Year 2007, Vol 7, Issue 3
Abstract
Objectives: To determine whether antiphosphatidyl serine autoantibodies (aPS) are associated with increased risk of occurrence of coronary events in selected patients. Methods: Tis study compared 50 patients with coronary events with 30 controls, recruited from the cities of Mosul, Erbil, and Dohuk cities, Northern Iraq, between March 2004 and March 2005. Te patient group consisted of 23 individuals with myocardial infarction and 27 with angina. We evaluated the presence of aPS antibodies (IgG and IgM isotypes) by an enzyme-linked immunosorbent assay. Te studied cases were less than 50 years of age (mean ± SD, 39.6 ± 5.9) and had no recognizable risk factors. Results: Te frequency of detecting IgG aPS was 0/50 (20%) among patients and /30 (3.3%) among controls, with significant difference and with adjusted odds ratio (OR) of 3.2 (95%CI, .-9.; p < 0.05). Te IgM aPS frequency was 3/50 (6%) among patients and zero in the controls, with non-significant difference. Te three cases were also IgG positive (i.e. the frequency rate for detection of aPS of IgM was the same as for IgG). Moreover, this marker (aPS) was detected in 8/2 (66.7%) of cases with unstable angina, in 2/5 (3.3%) with stable angina, and in none of the cases with myocardial infarction. Conclusion: IgG aPS autoantibodies are associated with increased risk of coronary events especially angina of unstable subset.
Authors and Affiliations
Hisham Y M Ali| College of Medicine, University of Dohuk, Kurdistan Region, Iraq, Zainalabideen A Abdullah| College of Medicine, University of Mosul, Iraq
Keywords
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