Antiplasmodial Activity and Phytochemical Constituents of Selected Antimalarial Plants Used by Native People in West Timor Indonesia
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2021, Vol 18, Issue 1
Abstract
Objectives: To document traditional antimalarial plants used by Tetun ethnic people in West Timor Indonesia and evaluate the antiplasmodial activity and phytochemicals of several plants that are widely used as oral medicine. Materials and Methods: A field study to document antimalarial plants followed by laboratory works to test antiplasmodial activity and identify the phytochemical constituents of some selected plants extract were applied. The inhibitory potency of ethanolic extracts of Strychnos ligustrina wood, roots of Calotropis gigantea, Fatuoa pilosa, and Neoalsomitra podagrica, whole plant of Cleome rutidosperma and Physalis angulata, stem barks of Alstonia spectabilis, Alstonia scholaris, Jatropha curcas and Plumeria alba, and leaves of Melia azedarach on the Plasmodium falciparum 3D7 strain in vitro were tested. Gas chromatography-mass spectrometry instrument was used to analyze the phytochemicals of the extracts. Results: The Tetun ethnic people use 50 plant species as antimalarials. P. angulata, J. curcas, and A. spectabilis extracts show strong antiplasmodial activity with IC50 values of 0.22, 0.22, and 1.23 μg/mL, respectively; N. podagrica, A. scholaris, F. pilosa, and P. alba were moderate antiplasmodials with IC50 values of 11.60, 15.46, 24.92, and 36.39 μg/mL, respectively; and C. rutidosperma, M. azedarach, S. ligustrina, and C. gigantea were weak antiplasmodials with IC50 values of 54.25, 63.52, 63.91, and 66.49 μg/mL, respectively. The phytochemicals identification data indicate that these 11 plants contain alkaloids, terpenoids, steroids, coumarins, alcohols, thiols, phenolics, aldehydes, fatty acids, esters, and so forth. Conclusion: Plants widely used as antimalarials by the Tetun ethnic people is proven to have antiplasmodial activity.
Authors and Affiliations
Maximus M. TAEK, Gerardus D. TUKAN, Bambang E. W. PRAJOGO, Mangestuti AGIL
Keywords
Related Articles
- EP ID EP693624
- DOI 10.4274/tjps.galenos.2019.29000
- Views 109
- Downloads 0
Formulation and In Vitro Evaluation of Telmisartan Nanoparticles Prepared by Emulsion-Solvent Evaporation Technique
Objectives: Telmisartan (TLM) is an antihypertensive drug that has been shown to have antiproliferative effects on cancer cells. It has low solubility and suboptimal oral bioavailability. To investigate the potential ant...
The Effect of Therapeutic Plasma Exchange on COVID-19 Therapy
No summary
Comparison of Lipid and Lipoprotein Values of Wrestlers and Soccer Players
Objectives: The aim of this study was to compare the lipid and lipoprotein values of wrestlers and soccer players. Materials and Methods: A total of 35 subjects, 17 male wrestlers who are sporting for 11.5 years and 18...
Decreased Protein Kinase C Expression in the Cochlear Fibroblasts of Diabetic Rat Models Induced by Curcumin
Objectives: Microcirculation and hemodynamic disturbances, including in the cochlea, are commonly found in diabetic patients. A study on diabetic rats discovered histopathological changes in outer hair cells and the spir...
Comparative In Vitro Assessment of the Methanol Extracts of the Leaf, Stem, and Root Barks of Cnidoscolus aconitifolius on Lung and Breast Cancer Cell Lines
Objectives: Cnidoscolus aconitifolius Mill. I.M.Johnst. is a medicinal plant widely used in ethnomedicine for the treatment of cancer and other diseases. Materials and Methods: The effects of methanol extracts of the le...