ANTIPLASMODIAL ACTIVITY OF THE ETHANOL LEAF EXTRACT OF NEWBOULDIA LAEVIS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 4
Abstract
Malaria is a parasitic protozoan disease caused by the protozoan parasites belonging to the genus Plasmodium. It is a major threat to health and constitutes medical and developmental challenge to individuals, communities and nations. Newbouldia laevis is an ethno-medicinal plant widely used in the treatment of malaria and other ailments. Phytochemical screening and antiplasmodial studies were carried out on the crude and fractions of the leaf extract of the plant using standard procedures. The phytochemical screening revealed the presence of alkaloids, saponins, glycosides, tannins, terpenes, flavonoids and carbohydrates in varying proportions. The crude extract exhibited a dose-dependent antiplasmodial activity against the parasite on all the models. The fractions also exhibited antiplasmodial activities with the ethyl acetate fraction showing the best antiplasmodial activity which is comparable to the standard drug. From the results obtained, Newbouldia laevis leaf is a good source of phytochemicals and also a potential source of potent antiplasplasmodial compounds that could be developed into drugs useful for the treatment of malaria.
Authors and Affiliations
Arnold C. Igboasoiyi
Keywords
Related Articles
- EP ID EP618024
- DOI -
- Views 192
- Downloads 0
ROLE OF POLYOLS AND SURFACTANTS IN LIQUID PROTEIN FORMULATIONS
in aqueous protein formulations, increase conformational stability of proteins by size exclusion mechanism, increasing thermodynamic stability of proteins and decreasing aqueous solubility. Polyols prevent protein aggreg...
TREATMENT OF TEMPOROMANDIBULAR JOINT DYSFUNCTION CASES AT TEACHING HOSPITAL, AL-KHOMS, LIBYA
The Temporomandibular joint is the joint that connects your jaw to your skull. When this joint is injured or damaged, it can lead to a localized pain disorder called Temporomandibular joint dysfunction (TMJD). It is char...
INDUSTRIAL PROCESS VALIDATION IN SOLID DOSAGE FORM: A REVIEW
The present article gives an introduction and general overview on process validation of pharmaceutical manufacturing process especially tablet manufacturing process. The concept of validation was first proposed by Food a...
A NOVEL APPROACH IN THE TREATMENT OF ORAL CANCER- GENE THERAPY AN UPDATE
Gene therapy “the use of genes as medicine” involves the transfer of a therapeutic or working copy of a gene into specific cells of an individual in order to repair a faulty gene copy. Many experiments have been done wit...
ANALYSIS OF APPLIED MEDICAL REHABILITATION IN CASES OF OBSTETRIC BRACHIAL PLEXUS LESION – ERB-DUCHENNE PALSY
The aim of this study is to present the methods of medical rehabilitation and the results from methodical administration in cases of Duchenne-Erb palsy, with damaged C5 and C6 roots. From 2011 to 2016 we have administere...