Antiplasmodial Potential and Phytochemical Screening of Ten Plants Used as Antimalarial in Mali
Journal Title: European Journal of Medicinal Plants - Year 2017, Vol 19, Issue 4
Abstract
Aim: This study was designed to determine in vitro antiplasmodial activities of extracts from ten Malian medicinal plants against P. falciparum strains. Place and Duration of Study: Collection of plant materials and basic phytochemical screening were done in Bamako, Mali and antiplasmodial activity assessment at Department of Microbiology and Immunology, Weill Cornell Medicine, New York, United States of America between September 2013 and February 2014. Methods: We collected leaves from ten commonly used medicinal plants and prepared ethanol and aqueous extracts. Antiplasmodial activities were evaluated against the chloroquine-sensitive 3D7 P. falciparum and chloroquine-resistant Dd2 P. falciparum strains, using the fluorescence-based SYBR® green I method. The interactions involving the differential extracts were further analyzed using a variable potency ratio drug combination approach. Chemical screening allowed us to identify the major secondary metabolites from those extract that were active against the parasite. Results: Plant extracts showed a range of antiplasmodial activity. The ethanol extracts of Annona senegalensis, Bauhinia thonningii, Maytenus senegalensis, and Fluenggea virosa showed moderate antiplasmodial activity against 3D7 P. falciparum (17.81±3.43≤IC50 ≤ 37.64±0.83 µg/mL) and against Dd2 P. falciparum strains (19.58±3.43≤ IC50 ≤ 67.55±.1.76 µg/mL). Among aqueous extracts only extract from Bauhinia thonningii demonstrated moderate antiplasmodial activity against both strains. The results showed that the active extracts contained a group of alcaloids, flavonoids, sterols, saponosides, tannins, coumarins and triterpenoids Conclusion: Bauhinia thonningii, Maytenus senegalensis, Annona senegalensis and Fluenggea virosa possess antiplasmodial activity. These data confirm their use in traditional malaria therapy in Mali and provide evidence for further study for antimalarial drug discovery.
Authors and Affiliations
Mamadou Wele, Laura Kirkman, Nouhoum Diarra, Yaya Goita, Moriba Doumbia, Kassim Traore, Drissa Diallo
Keywords
Related Articles
- EP ID EP327213
- DOI 10.9734/EJMP/2017/34523
- Views 134
- Downloads 0
Lemon Balm (Melissa officinalis L.) Water Requirement, Crop Coefficients Determination and SIMDualKc Model Implementing
The crop water requirements and coefficients should be determined for proper irrigation management and scheduling. The present study was conducted to determine water requirements, and single and dual crop coefficients of...
Neuropharmacological Activities of Ethanolic Extract of Cola millenii Dried Leaf in Rats
Objective: The leaf of Cola millenii is used in ethnomedicine to treat several ailments including; infections, fever and pain among several other diseases in Southwest Nigeria. Preliminary report indicates that the ethan...
Study of Antioxidant Activity of Essential Oils Extracted from Moroccan Medicinal and Aromatic Plants
Morocco contains a wide wealth of aromatic and medicinal plants; they constitute natural components, its valorization request a perfect knowledge of the properties to put in value. The present work has been the objective...
Antibacterial and Antifungal Activity of Litsea monopetala Leaves on Selected Pathogenic Strains
Aims: To evaluate the antibacterial and antifungal activity of some solvent extracts of Litsea monopetala (LM) leaves. Study Design: Examination of antibacterial and antifungal activity of petroleum ether fraction (PEF),...
A Review on Iranian Carum copticum (L.): Composition and Biological Activities
Aims: This paper examined thoroughly chemical composition and biological properties of Carum copticum. Study Design: Introduction on curtain characteristic of medicinal Ajowan (Carum copticum (L.)). Place and Duration...