Antiplasmodial Potential and Phytochemical Screening of Ten Plants Used as Antimalarial in Mali

Journal Title: European Journal of Medicinal Plants - Year 2017, Vol 19, Issue 4

Abstract

Aim: This study was designed to determine in vitro antiplasmodial activities of extracts from ten Malian medicinal plants against P. falciparum strains. Place and Duration of Study: Collection of plant materials and basic phytochemical screening were done in Bamako, Mali and antiplasmodial activity assessment at Department of Microbiology and Immunology, Weill Cornell Medicine, New York, United States of America between September 2013 and February 2014. Methods: We collected leaves from ten commonly used medicinal plants and prepared ethanol and aqueous extracts. Antiplasmodial activities were evaluated against the chloroquine-sensitive 3D7 P. falciparum and chloroquine-resistant Dd2 P. falciparum strains, using the fluorescence-based SYBR® green I method. The interactions involving the differential extracts were further analyzed using a variable potency ratio drug combination approach. Chemical screening allowed us to identify the major secondary metabolites from those extract that were active against the parasite. Results: Plant extracts showed a range of antiplasmodial activity. The ethanol extracts of Annona senegalensis, Bauhinia thonningii, Maytenus senegalensis, and Fluenggea virosa showed moderate antiplasmodial activity against 3D7 P. falciparum (17.81±3.43≤IC50 ≤ 37.64±0.83 µg/mL) and against Dd2 P. falciparum strains (19.58±3.43≤ IC50 ≤ 67.55±.1.76 µg/mL). Among aqueous extracts only extract from Bauhinia thonningii demonstrated moderate antiplasmodial activity against both strains. The results showed that the active extracts contained a group of alcaloids, flavonoids, sterols, saponosides, tannins, coumarins and triterpenoids Conclusion: Bauhinia thonningii, Maytenus senegalensis, Annona senegalensis and Fluenggea virosa possess antiplasmodial activity. These data confirm their use in traditional malaria therapy in Mali and provide evidence for further study for antimalarial drug discovery.

Authors and Affiliations

Mamadou Wele, Laura Kirkman, Nouhoum Diarra, Yaya Goita, Moriba Doumbia, Kassim Traore, Drissa Diallo

Keywords

Related Articles

Autophagy Inhibition Enhances the Mitochondrial-Mediated Apoptosis Induced by Mangrove (Avicennia marina) Extract in Human Breast Cancer Cells

Aims: Avicennia marina (AM) is a widely distributed mangrove plant that has been used in traditional medicine for centuries for the treatment of a number of diseases. The objective of the present study was to evaluate th...

Evaluation of the Anticonvulsant Potential of Aqueous Fraction of Synsepalum dulcificum Seed Extract in Mice

Aim: This study evaluated the anticonvulsant potential of the aqueous fraction of Synsepalum ducificum seed extract in mice. This was with a view to providing information on the possible link between the antioxidant prin...

Characterization of Phenolic Compounds of Ulva rigida (Chlorophycae) and Its Antioxidant Activity

Ulva rigida is a worldwide distributed green alga and is commenly used for human nutrition. Extracts of this seaweed were shown anti-hypercholestierinemic, antioxidant and anti-hyperglycemic activities. The antioxidant e...

Phytochemical and Anti-microbial Screening of the Leaves and Twigs of Sclerocarpus africanus (Jacq)

Aim: To determine phytochemical constituents and antimicrobial activity of leaves and twigs of Sclerocarpus africanus (Jacq); prove or otherwise ethno-medicinal claims on S. africanus. Place and Duration of Study: Depa...

In-vitro Evaluation of Antioxidant Potency of Organic Extracts of Leaves of Corchorus depressus Linn.

Aim: Evaluation of free radical scavenging and lipid peroxidation inhibitory activities of commercially available leaves of Corchorus depressus Linn. by in-vitro chemical analysis. Methodology: Four different solvent ext...

Download PDF file
  • EP ID EP327213
  • DOI 10.9734/EJMP/2017/34523
  • Views 144
  • Downloads 0

How To Cite

Mamadou Wele, Laura Kirkman, Nouhoum Diarra, Yaya Goita, Moriba Doumbia, Kassim Traore, Drissa Diallo (2017). Antiplasmodial Potential and Phytochemical Screening of Ten Plants Used as Antimalarial in Mali. European Journal of Medicinal Plants, 19(4), 1-9. https://europub.co.uk/articles/-A-327213