ANTIPSYCHOTIC POTENTIALS OF OCIMUM SANCTUM LEAVES
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2015, Vol 7, Issue 1
Abstract
The present study was undertaken to evaluate the antipsychotic potential of Ocimum sanctum in experimental animal models. Male Wistar rats (180-220 g) and albino mice (25-30 g) were used for the study. The antipsychotic effect of the Ocimum sanctum was evaluated on haloperidol induced catalepsy, cooks pole climbing apparatus, locomotor activity on actophotometer, ketamine induced stereotype behavior. Different groups of rats were fed orally with a specially prepared diet containing various concentrations (2% w/w, 4% w/w and 8% w/w) of Ocimum sanctum leaves paste (OCLP) for 15 consecutive days. Further, the biochemical estimations were done by estimating brain dopamine levels. The OCLP produced significant dose dependent potentiation of haloperidol (1mg/kg, i.p.) induced catalepsy in rats, significantly increased the time taken by the rat to climb the pole in dose dependent manner, significantly decreased the locomotor activity. The OCLP significantly decreased ketamine (50 mg/kg, i.p.) induced stereotyped behavior in a dose dependent manner. Ocimum sanctum leaves paste (OCLP) significantly decreased the brain dopamine levels. The results suggest that OCLP posse’s antipsychotic activity. Further neurochemical investigation can explore the mechanism of action of the plant drug with respect to anti-dopaminergic functions and help to establish the plant as an antipsychotic agent.
Authors and Affiliations
Renu Kadian, Milind Parle
Keywords
Related Articles
- EP ID EP625039
- DOI -
- Views 38
- Downloads 0
ANTIMICROBIAL ACTIVITY OF WHOLE PLANT OF LUFFA CYLINDRICA (LINN) AGAINST SOME COMMON PATHOGENIC MICRO-ORGANISMS
In this present investigation was to evaluate the antimicrobial activity of pet ether and chloroform extract of whole plant of Luffa cylindrica (Linn) by in-vitro method in agar plate against ten bacterial and four funga...
A VALIDATED STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT FOR ANTI CANCER DRUG ENZALUTAMIDE IN BULK AND PHARMACEUTICALS
A reproducible stability-indicating Reverse Phase-HPLC technique for the quantification of enzalutamide in in pharmaceuticals was developed and validated. Chromatography was achieved on Inertsil-ODS-C18 (250mm×4.6 mm) 5µ...
FORMULATION & EVALUATION OF MOUTH DISSOLVING TABLETS CONTAINING LOSARTAN POTASSIUM USING NATURAL SUPERDISINIGRANTS
Losartan potassium is used as an antihypertensive drug but it goes under first pass metabolism due do which it has low bioavailability. Fast onset of action is major concern in the management of hypertension. Therefore t...
In vivo Evaluation of Tazarotene Solid Lipid Nanoparticles Gel For Topical Delivery
The purpose of this research work was to develop and optimize the Solid Lipid Nanoparticles (SLNs) of Tazarotene for the effective topical delivery in the treatment of psoriasis. Tazarotene loaded SLNs were prepared by h...
GASTRORETENTIVE DRUG DELIVERY SYSTEM OF LEVO-SALBUTAMOL SULPHATE: FORMULATION AND IN VITRO EVALUATION
In order to prepare the sustained release tablet with levo-salbutamol sulphate we have used these excipients methylcellulose, PVPK30, magnesium stearate, talc, isopropyl alcohol, microcrystalline cellulose, lactose, HPMC...