Antiresorptive and Anabolic Bone Therapy Does not Improve Weight Bearing Capacity and Bone Strength in OA Rats
Journal Title: Open Journal of Orthopedics and Rheumatology - Year 2016, Vol 1, Issue 1
Abstract
Objective: This manuscript reports the outcomes of medial meniscectomy (MM) surgery on cartilage and cortical bone strength and the reaction of cartilage and bone to intensive treatment with antiresorptive (zoledronate) and anabolic bone (PTH) therapies. Methods: Medial meniscectomy was used to induce OA in male Lewis rats. Therapy with zoledronate and human PTH was initiated immediately after surgery. A dynamic weight-bearing system was deployed to evaluate the weight-bearing capacity. At the end of the 10-week study cartilage pathology was evaluated by contrast µCT imaging and histology. Cortical bone geometry at femoral mid-diaphysis was evaluated by µCT and strength was tested using 3-point bending method.
Authors and Affiliations
Bagi Cedo M, Berryman Edwin, Liu Chang-Ning, Zakur David E, Andresen Catharine J
Keywords
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- EP ID EP544705
- DOI 10.17352/ojor.000002
- Views 41
- Downloads 0
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