Antiseptic properties of aminoadamantane derivative
Journal Title: Фармацевтичний журнал - Year 2017, Vol 5, Issue 5
Abstract
Development of microbial resistance to current antimicrobial drugs created a critical need of the new antiseptics. The object of our study was phenyladamantane derivative (4-(adamantyl-1)-1-(1-aminobutyl)benzol, AM-166). The aim of the presented study was to investigate the specific activity of 4% AM-166 solution in isopropanol and 5% AM-166 solution in 76% ethanol (manufactured by PJSC SIC «Borshchahivskiy CPP») against the wide spectrum of bacteria and fungi, and effective concentrations and exposition time determination. Desinfectant/antiseptic activity was evaluated by quantitative suspension method with subsequent neutralization. Our results showed that both solutions exhibited similar activity against gram-positive and gram-negative bacteria as well as against yeasts. Antibacterial and antifungal action was demonstrated for all investigated concentrations (initial solution, 5-fold and 10-fold dilutions), observed effect was maintained throughout the whole observation period (from 5 to 30 min). Tested solutions in initial concentrations demonstrated fungicidal activity against A. niger. 5-fold dilution of 5% AM-166 solution in 76% ethanol was more effective than 5-fold dilution of 4% AM-166 solution in isopropanol. 10-fold dilutions of both solutions were ineffective against A. niger. The data obtained suggest the prospects of adamantane derivatives for the development of novel antiseptics.
Authors and Affiliations
N. O. Vrynchanu, V. L. Makitruk, A. S. Shalamay, M. L. Dronova, D. M. Dudikova, Z. S. Suvorova, A. O. Sharova
Keywords
Related Articles
- EP ID EP556081
- DOI 10.32352/0367-3057.5-6.17.06
- Views 75
- Downloads 0
The research of anti-inflammatory activity of 5-(5-bromofuran-2-yl)-4-ethyl-1,2,4-triazole-3-thion S-derivatives
The studing of anti-inflammatory activity of the novel compounds may give rise to the using of safer and more active drugs in the treatment of diseases which are shown NSAIDs. To further study the pharmacological prope...
Development of the composition and production technology of injection medication for intra-articular introduction based on sodiun hyaluronate
Osteoarthrosis is the most widespread disease of musculoskeletal system, which leads to different level of disability in 10–30% of cases. The age of the person is one of the key risk factors for the development of such d...
Using the thermal methods of analysis in selecting the optimal production techniques for tablets based on ademetionine 1,4-butanedisulfonate substance
When developing tablets on the base of ademetionine 1.4-butandionsulfonat substance it is difficult to obtain a stable product, as substance is hygroscopic, and its quantity in the tablet is 90% by weight of the core. T...
Multiple criteria decision analyisis for health technology assessment: scientific substantiation of criteria selection in Ukraine
Multiple-criteria decision analysis (MCDA) is a framework where multiple criteria are being considered in a well-structured manner during the decision-making process. This methodology is becoming increasingly popular for...
Testing of the mutagenic potential of N-(γ-aminobuturyl)-1-aza-15-crown-5 hydrochloride in Ames test microplate modification
In recent years, studies in the field of chemical mutagenesis have undergone significant development, due to the introduction of a large number of different chemicals and scientific advances in the creation and use of ne...