Antistaphylococcal Activity of Selected Thiourea Derivatives
Journal Title: Polish Journal of Microbiology - Year 2016, Vol 65, Issue 4
Abstract
Five of thiourea derivatives were prepared using as a starting compound 3-(trifluoromethyl)aniline, 4-chloro-3-nitroaniline, 1,3-thiazol-2-amine, 2H-1,2,3-triazol-4-amine and commercial isothiocyanates. All compounds were evaluated in vitro for antimicrobial activity. Derivatives 2 and 3 showed the highest inhibition against Gram-positive cocci (standard and hospital strains). The observed MIC values were in the range of 0.5–8 μg/ml. The products effectively inhibited the formation of biofilms of methicillin-resistant and standard strains of Staphylococcus epidermidis. Inhibitory activity of thioureas 2 and 3 against Staphylococcus aureus topoisomerase IV was studied. The examined compounds were nongenotoxic.
Authors and Affiliations
Joanna Stefańska, Karolina Stępień, Anna Bielenica, Małgorzata Wrzosek, Marta Struga
Role of SAP7 in Hypha Formation and Adhesion to Colorectal Carcinoma Caco-2 (ATCC)
Secreted aspartic proteases (Saps) are considered as key virulence factors of [i]Candida albicans[/i]. Hopefully our outlook will widen the knowledge of [i]SAP7’[/i]s role in [i]C. albicans[/i] pathoge...
Bacterial Diversity and Abundance in Shell Biofilms from the Freshwater Snail Pleurocera canaliculatum (Cerithioidea: Pleuroceridae)
Mollusk shells provide a hard substrate for aquatic biofilm colonization. While most work has focused on bivalve shells and grazing, little work has focused on gastropod shells and the microbes growing on them. We s...
Microbial Glycosylation of Flavonoids
Flavonoids constitute a large group of polyphenolic compounds naturally found in plants, which have a wide range of biological activity. Although flavonoids are beneficial to human health, their application is limited by...
Role of SAP7-10 and Morphological Regulators (EFG1, CPH1) in Candida albicans’ Hypha Formation and Adhesion to Colorectal Carcinoma Caco-2
Secreted aspartic proteases (Saps) are considered as key virulence factors of Candida albicans. Hopefully our outlook will widen the knowledge of SAP7’s role in C. albicans pathogenesis. The goal of our study was to inve...
Characteristics of the Pseudomonas aeruginosa PA01 Intercellular Signaling Pathway (Quorum Sensing) Functioning in Presence of Porphyrins Bismuth Complexes
The influence of synthetic and natural porphyrins bismuth complexes on [i]P. aeruginosa[/i] quorum sensing system was carried out by detection of the pyocyanin, rhamnolipids and autoinducers biosynthesis level. The...