Antithrombin-III level and Platelet Count in Pregnancy Induced Hypertension (PIH): A Cross-Sectional Study from a Tertiary Care Centre of North-Eastern India
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Pregnancy Induced Hypertension (PIH) is one of the most common disorders seen in human pregnancies. Approximately 1,00,000 women die worldwide per annum because of eclampsia. It is said that pre-eclampsia and eclampsia contribute to death of a woman every 3 minute worldwide. In India the incidence of pre-eclampsia is reported to be 8-10% of the pregnancy. It is the third leading cause of maternal mortality responsible for 17% of maternal deaths. Hence, this study was undertaken to determine the changes in the level of plasma Antithrombin-III and Platelet count in pre-eclamptic woman and its correlation with severity of disease in order to evaluate if it can be used as a marker of severity of pregnancy induced hypertension (PIH). Material and Methods: Total 90 PIH cases in their third trimester of pregnancy comprising of 30 Mild Pre-eclampsia, 30 Severe Pre-eclampsia and 30 Eclampsia patients were enrolled for the study. The necessary laboratory investigations required for the study was carried out in the Advanced Hematology, Service Laboratory under Department of Pathology in a tertiary care centre of North-eastern India by using SYSMEX XS-800i 5 part haematology analyzer and SYSMEX CA-500 series Coagulometer. Data were analyzed using MS Excel 2007 and GraphPad Prism 7. Results: In PIH patients Antithrombin-III level and Platelet count shows a gradual and almost linear reduction in various groups ranging from mild pre-eclampsia to eclampsia. Conclusion: It was concluded from the study that the reduction of platelet count and antithrombin-III are the main predictors to predict and monitor the severity of PIH.
Authors and Affiliations
Upam Kr. Sharma, Arpita Nath
Keywords
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