Antitrypanosomal Activity of Allium porrum Ethyl Acetate Bulb Extract in Trypanosoma brucei brucei Experimentally Infected Wister Albino Rats
Journal Title: European Journal of Medicinal Plants - Year 2017, Vol 19, Issue 4
Abstract
Aims: The present study investigated the antitrypanosomal activity of crude ethyl acetate bulb extracts of A. porrum plant against T. b. brucei. Methodology: Twenty five male albino rats were divided into five groups and infected with x106/ml of T. b. brucei. Group 1 was infected and untreated while groups 2-4 were infected and treated with single intraperitoneal injection 50, 75 and 100 mg/kg of ethyl acetate extract of A. porrum while a single dose 3.5 mg/kg diaminazene aceturate was administered to group 5 when parasitaemia was established at x106 day 5 post infection. Results: Clinical manifestations of trypanosomoses such as increased rectal temperature, weakness and dullness were observed in experimental rats in all the groups. There was decrease packed cell volume (PCV) and red blood cell count (RBC) in group 1-4 which was not significant (p>0.05) while group 5 had a significant increase (p<0.05) in PCV and non-significant increase (p>0.05) in RBC post treatment. There were feeble changes in the pre-treatment and post-treatment parasitemia level in the groups treated with ethyl acetate extract of A. porrum while there was significant clearance in parasitemia in the control group. Conclusion: Interperitoneal injection of ethyl acetate extracts of A. porrum at the dose and concentration used in this study, has trypanosomal reduction activity in wister rats.
Authors and Affiliations
S. Odeyemi Omonike, A. Umar Yahaya, M. S. Abdulsalami
Keywords
Related Articles
- EP ID EP327230
- DOI 10.9734/EJMP/2017/34418
- Views 128
- Downloads 0
Phytochemical and Anti-diarrhoeal Properties of Methanolic Leaf Extract of Maerua crassifolia Forssk
Maerua crassifolia Forssk. Leaf is used in African traditional medicine for management of gastrointestinal disorders. The anti-diarrhoeal activity of the methanol extract of Maerua crassifolia leaf was investigated in ra...
Hypoglycemic and Hypolipidemic Activities of Methanolic Extract of Sphenocentrum jollyanum on Streptozotocin-induced Diabetic Wistar Rats
Aims: This study is to provide scientific basis for the folkloric use of Sphenocentrum jollyannum roots in the management and/control of Diabetes mellitus. The effects of the extract on blood glucose level and serum lipi...
2, 2-Diphenyl-1-picrylhydrazyl Radical Effect and Phytochemical Constituents of Combretum platypetalum Welw. ex. M. A. Lawson subsp. oatesii (Rolfe) Exell Leaf
Aims: To investigate the phytochemical constituents and antioxidant properties of Combretum platypetalum leaf. Study Design: In vitro assessment of antioxidant properties and determination of the phytochemical constitue...
Ashwagandha and Its Active Ingredient, Withanolide A, Increase Activation of the Phosphatidylinositol 3’ Kinase/Akt Cascade in Hippocampal Neurons
Aims: To determine if whether, in a hippocampal neuron culture model subjected to nutrient deprivation stress (simulating degenerative disease state), Ashwagandha and/or two of its putative active ingredients, withanolid...
Effect of Methanolic Leaf Extract of Carica papaya on Plasmodium berghei Infection in Albino Mice
Aim: The work was designed to investigate the antmalarial activity of methanolic leaf extract of Carica papaya on Plasmodium berghei NK65 strain infection in vivo. Place and Duration of Study: Department of Biochemistry...