ANTIULCER ACTIVITY OF PETROLEUM ETHER EXTRACT OF BETA VULGARIS (L.)
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2016, Vol 5, Issue 6
Abstract
Objectives: The present study was designed to evaluate the antiulcer activity of petroleum ether extract of Beta vulgaris L. Methods: Present study was designed to investigate the antiulcer activity of petroleum ether extract of Beta vulgaris L. Wistar rats were used and divided into three groups. Group one to three received tween 80 (negative control), aspirin (Positive control), and 200mg/kg of petroleum ether extract of Beta vulgaris and aspirin respectively. After 12h fasting period, aspirin 200mg/kg orally administered to group two and three. Rats were sacrificed 5h after aspirin treatment. Stomach was analyzed for histological changes. Results: Aspirin control shown damaged gastric architecture with dead neutrophils and pus formation of gastric mucosal layer, whereas rats pretreated with petroleum ether extract showed few inflammatory cells presented only in the base of the mucosal layer. Conclusion: Results of this study showed that, pretreatment with petroleum ether extract of Beta vulgaris L. provided moderate significant protection against aspirin induced gastric ulcers.
Authors and Affiliations
Jagan Nadipelly| Department of Pharmacology, MNR Medical College and Hospital, Fasalwadi, Sangareddy, Medak, Ambareesha K| Department of Physiology, MNR Medical College and Hospital, Fasalwadi, Sangareddy, Medak, Jyothinath Kothapalli| Department of Anatomy, MNR Medical College and Hospital, Fasalwadi, Sangareddy, Medak
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