ANTIULCEROGENIC AND ANTIULCER ACTIVITIES OF DISSOTIS THOLLONII (MELASTOMATACEAE) LEAVES IN RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 8
Abstract
Objective: Dissotis thollonii is used in Cameroonian ethnomedicine to cure diseases such as inflammations, pregnancy control, diarrhea and gastric ulcer. The aqueous and methanol leaf extracts were evaluated for their anti ulcerogenic and antiulcer activities.Methods: The extracts were administered at the doses of 125, 250 and 500 mg/kg to evaluate their effects on gastric ulcer induced by the HCl/ethanol mixture, indomethacin and acetic acid in rats. Ranitidine, Maalox and Misoprostol were used as standard drugs. Histopathological examination and nitric oxide level was performed to evaluate the basic action mechanism of Dissotis thollonii.Results: Oral administration of the plant dose-dependently prevented HCl/ethanol-induced gastric ulcers (72.15 to 100 % for aqueous extract and 68.78 to 89.60 % for methanol extract), Indomethacin (51.13 to 100 % for aqueous extract and-32.33 to 58.45 % for methanol extract). The extracts also promoted the healing and cicatrization process in chronic gastric ulcer induced by acetic acid and increased the NO level in plasma. Histological studies of the gastric wall revealed that ulcer control group exhibited severe damage of the gastric mucosa, compared to rats pre-treated with extracts, which comparatively showed gastric mucosal protection.Conclusion: Dissotis thollonii possess protective and healing activities in rats. The anti ulcerogenic activity may be attributed to the stimulation of the prostaglandins synthesis and antiulcer property to increase NO level in plasma. Histological investigation of gastric lesion shows that the plant stimulates the cicatrizing process. These results supported the ethnomedicinal uses of Dissotis thollonii in the treatment of gastric ulcers.Â
Authors and Affiliations
Ateufack Gilbert, Mikwangock Domegne Hauberline M. , Dongmo Feudjio Breuil R, Yousseu Nana William, Kamanyi Albert
Keywords
Related Articles
- EP ID EP578243
- DOI -
- Views 71
- Downloads 0
EVALUATION OF THE ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF CENTELLA ASIATICA IN ALBINO MICE
Objective: To evaluate the antiepileptic activity of aqueous extract of Centella asciatica in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced convulsions. Methods: The anticonvulsant activity of leaves of...
CHARACTERIZATION OF THE MUCILAGES EXTRACTED FROM HIBISCUS ROSA-SINENSIS LINN AND HIBISCUS MUTABILIS LINN AND THEIR SKIN MOISTURIZING EFFECT
Objective: The present study was aimed to investigate the physicochemical properties, chemical characterization and skin moisturizing effect of the mucilages extracted from Hibiscus rosa-sinensis (HR), and H. mutabilis (...
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS OF NOVEL PYRAZOLINE DERIVATIVES USING K NEAREST NEIGHBOUR MOLECULAR FIELD ANALYSIS METHOD
Objective: Malonyl CoA decarboxylase (MCD) enzyme plays important role in fatty acid and glucose oxidation. Inhibition of MCD might turn to a novel approach to treat ischemia. The main objective of this research article...
COMPARATIVE DOCKING STUDIES ON THE EFFECT OF COMMERCIAL DRUGS ON DIPEPTIDYL PEPTIDASE-4 (DPP-4)
Objective: The aim of our study was to validate the accuracy of computational tools in drug discovery and molecular interaction studies by studying the inhibitory activity of various commercial drugs on DPP-4.Methods: In...
ANTIOXIDANT THERAPEUTIC ACTIONS OF MEDICINAL PHYTOCHEMICALS, SILYMARIN AND SILIBININ, ON STREPTOZOTOCIN DIABETIC RATS: FIRST NOVEL COMPARATIVE ASSESSMENT OF STRUCTURAL RECOVERIES OF HISTOLOGICAL AND ULTRASTRUCTURAL CHANGES ON ISLETS OF LANGERHANS, Î’-CELLS, MITOCHONDRIA AND NUCLEUS
Objective: We studied correlation between antioxidant properties of Silymarin and Silibinin and the restoration and recovery of normal structure of islets of Langerhans β-cells and mitochondria in Streptozotocin-diabeti...