Antler Stem Cells Sustain Regenerative Wound Healing in Deer and in Rats
Journal Title: Journal of Regenerative Biology and Medicine - Year 2020, Vol 2, Issue 1
Abstract
Deer antlers are unique mammalian appendages in that they can fully regenerate following loss from their pedicles (permanent bony protuberances). Antler regeneration starts from regenerative wound healing on top of a pedicle stump. A combination of tissue deletion and transplantation experiments showed that this type of regenerative healing is not skin-specific, but is bestowed by the pedicle periosteum (PP). PP cells express marker genes of both mesenchymal and embryonic stem cells, and can be induced to differentiate into multiple cell lineages in vitro. Therefore, PP cells are termed antler stem cells (AnSCs). Treatment of rats with full-thickness cutaneous wounds (2 - 2 cm) through either direct injection of AnSCs into the rats or topical application of conditioned medium of AnSCs on to the wounds can effectively induce regenerative wound healing. We believe our study has laid the foundations for developing an effective clinical therapy to achieve scar-less wound healing.
Authors and Affiliations
Chunyi Li*
Keywords
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- EP ID EP707319
- DOI https://doi.org/10.37191/Mapsci-2582-385X-2(1)-016
- Views 71
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