Apolipoprotein B / Apolipoprotein A-I Ratio a better Diagnostic Marker of Coronary Heart Disease than Conventional LDL/HDL Ratio
Journal Title: National Journal of Laboratory Medicine - Year 2016, Vol 5, Issue 3
Abstract
Introduction: Apolipoprotein B (Apo B) and apolipoprotein A-I (Apo-I) are cholesterol transporters playing an important role in lipid metabolism. Apo B and A-I represent the total atherogenic and non-atherogenic particles respectively. Hence, their ratio – Apo B/A-I has been strongly associated with various cardiovascular events. Aim: To compare the diagnostic efficacy of apolipoproteins with conventional lipids for coronary heart disease. Materials and Methods: There were 295 individuals with or without coronary heart disease were enrolled in the study. The demographic details along with clinical investigations of serum lipid parameters, Apo B and Apo A-I levels were obtained and recorded. Study Design: It was a single centre, prospective observational study of 295 individuals of both the genders (235 males and 60 females) with or without coronary artery disease. Statistical Analysis: A comparison of parametric values between two groups was performed using student’s t-test. Non-parametric analysis of the continuous data was performed using Mann-Whitney U test. Significance was taken as two tailed p<0.05. Results: In study population, 221(74.92%) had coronary heart disease (CHD) and 74(25.08%) were normal. Statistically significant differences were found in the levels of apo B/apo A-I ratio (p=0.009), and Apo A-I (p≤0.001) between two groups. The other lipid parameters and ratios such as cholesterol, triglyceride, HDL-C, LDL-C, nonHDL-C cholesterol, VLDL, Total lipid, Apo-B, LDL-C/HDL-C and TC/HDL-C were not found to be significant. Conclusion: The present study shows that Apo B/A-I possesses superior diagnostic efficacy for coronary heart disease as compared to conventional lipid parameters and could be effectively used in clinical practice.
Authors and Affiliations
Dr. Jayesh S. Prajapati, Dr. Jagjeet K. Deshmukh, Dr. Krutika H. Patel, Dr. Komal H. Shah, Dr. Hasit J. Joshi, Dr. Ranajeet More, Dr. Sibasis S. Sahoo
Keywords
Related Articles
- EP ID EP380014
- DOI 10.7860/NJLM/2016/17706:2130
- Views 105
- Downloads 0
Application of Probabilistic Approach in Reporting Breast Lesions on Fine Needle Aspiration Cytology: Institutional Study
Introduction: Cancer of breast is among the most common cancer throughout the world. In Indian women rising incidence of breast cancer remains a concern. Due to lack of health awareness and limited breast cancer screenin...
Altered Levels of Serum Adenosine Deaminase in Type 2 Diabetes Mellitus
ABSTRACT Introduction: Diabetes Mellitus (DM) is one of the leading not causes of increased morbidity and mortality in developing countries. Adenosine Deaminase (ADA) enzyme in purine metabolism catalyses the irreversibl...
Comparison of Methods of Biofilm Detection in Urinary Candida Isolates and Evaluating its Role in Persistent Candiduria
Introduction: Candiduria is a common finding in catheterised patients with increasing trend of non albicans Candida species. Biofilm formation on indwelling catheters leads to persistent colonisation ending up in infecti...
Clinico-mycological and Antifungal Susceptibility Profiles of Candiduria in A Tertiary Care Hospital From South India
Introduction: Candida is one of the common causative agent of Urinary Tract Infections (UTI) worldwide. The most common reported species causing UTI is Candida albicans. Incidence of UTI due to non-albicans Candida speci...
Right Ventricular Myxoma in an Asymptomatic Patient: A Rare Case Report
Myxomas are the most common primary tumours of the heart (40%). It usually occurs sporadically and are most commonly located in the left atrium (86%). Here, we report a 40-year-old male patient who was incidentally diagn...