Apolipoprotein B / Apolipoprotein A-I Ratio a better Diagnostic Marker of Coronary Heart Disease than Conventional LDL/HDL Ratio
Journal Title: National Journal of Laboratory Medicine - Year 2016, Vol 5, Issue 3
Abstract
Introduction: Apolipoprotein B (Apo B) and apolipoprotein A-I (Apo-I) are cholesterol transporters playing an important role in lipid metabolism. Apo B and A-I represent the total atherogenic and non-atherogenic particles respectively. Hence, their ratio – Apo B/A-I has been strongly associated with various cardiovascular events. Aim: To compare the diagnostic efficacy of apolipoproteins with conventional lipids for coronary heart disease. Materials and Methods: There were 295 individuals with or without coronary heart disease were enrolled in the study. The demographic details along with clinical investigations of serum lipid parameters, Apo B and Apo A-I levels were obtained and recorded. Study Design: It was a single centre, prospective observational study of 295 individuals of both the genders (235 males and 60 females) with or without coronary artery disease. Statistical Analysis: A comparison of parametric values between two groups was performed using student’s t-test. Non-parametric analysis of the continuous data was performed using Mann-Whitney U test. Significance was taken as two tailed p<0.05. Results: In study population, 221(74.92%) had coronary heart disease (CHD) and 74(25.08%) were normal. Statistically significant differences were found in the levels of apo B/apo A-I ratio (p=0.009), and Apo A-I (p≤0.001) between two groups. The other lipid parameters and ratios such as cholesterol, triglyceride, HDL-C, LDL-C, nonHDL-C cholesterol, VLDL, Total lipid, Apo-B, LDL-C/HDL-C and TC/HDL-C were not found to be significant. Conclusion: The present study shows that Apo B/A-I possesses superior diagnostic efficacy for coronary heart disease as compared to conventional lipid parameters and could be effectively used in clinical practice.
Authors and Affiliations
Dr. Jayesh S. Prajapati, Dr. Jagjeet K. Deshmukh, Dr. Krutika H. Patel, Dr. Komal H. Shah, Dr. Hasit J. Joshi, Dr. Ranajeet More, Dr. Sibasis S. Sahoo
Keywords
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- EP ID EP380014
- DOI 10.7860/NJLM/2016/17706:2130
- Views 106
- Downloads 0
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