Applicability of Lipoprotein (a) as a Risk Predictor for Cerebrovascular Disease
Journal Title: Scholars International Journal of Biochemistry - Year 2018, Vol 1, Issue 1
Abstract
Lipoprotein (a) is independently associated with Atherosclerotic Cardiovascular Disease (ASCVD) and is referred to as the most atherogenic lipoprotein. It is synergistic with the effects of low density lipoprotein cholesterol (LDL-C). Unlike other major classes of lipoproteins that have a normal distribution in the population, plasma levels of Lipoprotein (a) / Lp (a) have a skewed distribution towards the lower end with 85% population having concentration <30 mg/dL. The aim of present study is to estimate the level of serum Lp(a) in cerebrovascular diseases or Strokes. The study was conducted in the Department of Medicine, Department of Biochemistry, Sushila Tiwari Memorial Hospital, the teaching hospital of Uttaranchal Forest Hospital Trust (UFHT) Medical College, Haldwani (Nainital), Uttarakhand, on patients of cerebrovascular disease (CVD) which included estimation of Lp(a) and lipid profile (TC, TG, HDLc, LDLc, VLDLc) test. Out of the 17 women and 36 men in whom Lp (a) was measured, 2 women (mean age63.5 years) and 21 men (59years) had CVD (CVD(+), while 15 women (50.13 years) and 15 men (52.33 years) had no CVD [CVD(–)]. As shown in Table 1, there were no significant differences between women with or without CVD in age and concentration of total plasma cholesterol. The study was based on a small sized cohort of 23 cases suffering from (CVD) out of which 21 were males and 2 were females. Thirty (30) healthy subjects were taken as controls, who were not suffering from any disease, which may affect serum lipid levels and without any history of cerebrovascular disease. Total-C, LDLc, VLDLc, Triglyceride, HDLc, LDL/HDL, Cholesterol/HDL and Lp(a) were estimated in all the cases.
Authors and Affiliations
Sanjay Bhatt, V. S. singh, Sangeeta singh, S. R. Saxena, A. Joshi, Bindu Sati
Keywords
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