Application and development of 3D bioprinting in the field of spinal cord injury

Journal Title: Biomedical Transformation - Year 2022, Vol 3, Issue 2

Abstract

Spinal cord injury is the highly fatal and disabling neurological condition that often results in irreversible loss of sensory, motor and autonomic function. The immediate and secondary responses at the injury time result in a local cascade response in the spinal cord that inhibits nerve regeneration and tissue repair. Current surgical and pharmacological treatments fail to achieve the desired effect, meanwhile 3D bioprinting-based transplantation strategies are emerging as promising candidates for translational therapies. Neural tissue engineering research focuses on balancing the inhibitory microenvironment and effectively bridging the biological scaffold and nerve cells to repair spinal cord tissue structure and nerve cell function. Additive manufacturing fix the relative positions of components by precisely printing cells to regulate the growth states and promote differentiation and print specific neurotrophic molecules in the reserved apertures to form specific functional neural networks that can help improve functional recovery after spinal cord injury, which has high promise for clinical applications.

Authors and Affiliations

Wang Jianhao, Feng Shiqing

Keywords

Related Articles

The ins and outs of extracellular vesicles

Extracellular vesicles refer a population of vesicles bodies including ectosomes, apoptosis bod‐ ies, oncosomes and exosomes released by cells. And as an important intercellular signaling tool, they play vital roles in v...

Genetic polymorphisms and population genetic analyses in Chinese Kyrgyz group based on 35 InDel loci

Objective In order to evaluate the forensic efficiencies of 35 InDel loci in Chinese Kyrgyz group and analyze the genetic background of the Kyrgyz. Methods A total of 214 unrelated healthy individuals in Kyr‐ gyz group w...

Progress in diagnosis and treatment of androgenetic alopecia

Androgenetic alopecia (AGA) is a very common hair disease, which occurs in both males and females. The clinical manifestations of AGA mainly include miniaturization of hair, thinning of hair and upward movement of hairli...

Causal relationship between immune cells and obesity risk: Univariate bidirectional and multivariate Mendelian randomization study

Objective This study aims to explore the causal relationship between immune cells and obesity risk using the Mendelian randomization (MR) method. Methods Data sets for 731 types of immune cells and obesity were obtained...

Protein post-translational modification regulates HIV-1 latency

AIDS is a disease named acquired immunodeficiency syndrome, which caused by the human immunodeficiency virus (HIV). HIV can be divided into HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is a global pandemic that has c...

Download PDF file
  • EP ID EP766832
  • DOI 10.12287/j.issn.2096-8965.20220208
  • Views 13
  • Downloads 0

How To Cite

Wang Jianhao, Feng Shiqing (2022). Application and development of 3D bioprinting in the field of spinal cord injury. Biomedical Transformation, 3(2), -. https://europub.co.uk/articles/-A-766832