Application of Carrier and Plasticizer to Improve the Dissolution and Bioavailability of Poorly Water-Soluble Baicalein by Hot Melt Extrusion
Journal Title: AAPS PharmSciTech - Year 2014, Vol 15, Issue 3
Abstract
Baicalein (purity > 95%) was supplied by China Pharmaceutical University, Nanjing, China. Kollidon VA64, Soluplus, Cremophor RH, and Poloxamer 188 were friendly supplied by Basf Auxiliary Chemicals Co., Ltd., Shanghai, China. Eudragit EPO was a gift from Evonik Degussa Special Chemicals Co., Ltd., Shanghai, China. Hydroxypropyl methycellulose (HPMC) 2910 was kindly provided by Colorcon Co., Ltd., Shanghai, China. Polyethylene glycol (PEG) 2000 was purchased from Wanqing Chemical Development Co., Ltd, Nanjing, China.
Authors and Affiliations
Yilan Zhang, Rui Luo, Yi Chen, Xue Ke, Danrong Hu, Miaomiao Han
Keywords
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- EP ID EP682378
- DOI 10.1208/s12249-013-0071-x
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