Application Of Child - Turcotte Pugh Scale For The Assessment Of Severity Of Liver Dysfunction And Dosage Individualization
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 11
Abstract
The hepatic metabolism and clearance of drugs are altered in liver dysfunction which necessitates the need for assessment of severity of liver dysfunction and dosage individualization. The degree of hepatic impairment was calculated using Child-Pugh classification and the dose adjustments were per formed using the published drug dosing guidelines. The dosing interval or the total dose was adjusted when necessary. The degree of liver function impairment of 50 patients was assessed in the present study. Among the 545 drugs prescribed, the dosages of 40 (7.33%) were adjusted based on the severity of liver dysfunction. Spironolactone, torsemide, and rabeprazole were some of the drugs for which dose was adjusted in patients with hepatic function impairment. Medication chart review and concurrent feedback by the clinical pharmacist may result in enhanced medication safety and improved therapeutic outcome in patients with hepatic dysfunction.
Authors and Affiliations
Manjula Devi A. S, Radhakrishnan S, FibiPrisca Raj, Halin Nancy Jeba D, Jaean Ann Kennady, Jeethu Sunny
Keywords
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