Application of Molecular Techniques in Quality Control of Drugs of Natural Origin; A Review
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 20, Issue 6
Abstract
Pharmacognosy is a long established pharmaceutical science, which played a diverse role in the discovery, characterization, production and standardization of drugs. Molecular pharmacognosy using molecular biological tools has extended the scope of pharmacognostical science and plays an important role in the safe and efficient usage of crude drugs. So, these crude drugs are required to be authenticated. DNA Molecular profiling is an additional tool for quality control of herbal drugs as DNA is more basic component of living organisms, whereas chemical and phenotypic expression is controlled by arrangement and expression of genes in the DNA”. This novel approach has several significant advantages over morphological and chemical methods. It is possible to use DNA based identification methods to identify species and different constituents of an herbal medicines and transcriptomics, proteomics, metabolomics based methods for the functional analysis of key genes involved in synthesis of desired medicinal materials. It serves as a complementary tool to standardization of drugs.
Authors and Affiliations
Juwairiya Butt, Shumaila Arshad, Zulfiqar Ali Mir, Sophia Awais, Javed Iqbal, Saeed- Ul-Hassan
Keywords
Related Articles
- EP ID EP313095
- DOI 10.9734/JPRI/2017/38523
- Views 103
- Downloads 0
Antibacterial Potential of Bryophyllum pinnatum Leaf Extracts on Bacteria Obtained from Infected Infant Respiratory Tract
Background: Annual incidence of respiratory infection and death among infants aged between one (1) to two (2) years is increasing, especially in remote areas of the world. Herbal medicines have been the basis of treatmen...
Diclofenac-induced Gastric Ulceration in Rats: Protective Roles of Pantoprazole and Misoprostol
Gastrointestinal damage caused by diclofenac remains a significant clinical problem. Pantoprazole provides potent and long-lasting inhibition of gastric acid secretion and has proven efficacy in healing diclofenac-associ...
Treatment Persistence Associated with Typical versus Atypical Antipsychotics among Out-patients with Schizophrenia
Aim: The chronic nature of schizophrenia usually demands uninterrupted treatment in order to maintain optimal clinical and functional outcomes. It has been speculated that patients receiving atypical antipsychotics may p...
Factor Affecting Photo and Thermal Stability of Levothyroxine Sodium
The aim of this works is to study the thermal and photo-decomposition of levothyroxine sodium. The effect of light on the stability of the drug in solution was studied under conditions of several parameters (concentratio...
Isolation of Hopenone-I from the Leaves of Mangrove Plant Scyphiphora hydrophyllacea and Its Cytotoxic Properties
Aims: The present study was aimed to isolate active anti proliferative compound/s from the hexane extract of leaves of the mangrove plant Scyphiphora hydrophyllacea C.F.Gaertn. and evaluate their cytotoxic properties. Pl...