Application of Molecular Techniques in Quality Control of Drugs of Natural Origin; A Review
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 20, Issue 6
Abstract
Pharmacognosy is a long established pharmaceutical science, which played a diverse role in the discovery, characterization, production and standardization of drugs. Molecular pharmacognosy using molecular biological tools has extended the scope of pharmacognostical science and plays an important role in the safe and efficient usage of crude drugs. So, these crude drugs are required to be authenticated. DNA Molecular profiling is an additional tool for quality control of herbal drugs as DNA is more basic component of living organisms, whereas chemical and phenotypic expression is controlled by arrangement and expression of genes in the DNA”. This novel approach has several significant advantages over morphological and chemical methods. It is possible to use DNA based identification methods to identify species and different constituents of an herbal medicines and transcriptomics, proteomics, metabolomics based methods for the functional analysis of key genes involved in synthesis of desired medicinal materials. It serves as a complementary tool to standardization of drugs.
Authors and Affiliations
Juwairiya Butt, Shumaila Arshad, Zulfiqar Ali Mir, Sophia Awais, Javed Iqbal, Saeed- Ul-Hassan
Keywords
Related Articles
- EP ID EP313095
- DOI 10.9734/JPRI/2017/38523
- Views 106
- Downloads 0
Study of Bacterial Resistance in Clinical Isolates of Staphylococcus aureus by Comparison of Conventional in-vitro Methods with PCR & RFLP Based Genotypic Methods
Methicillin Resistant S. aureus is an increasingly common cause of nosocomial infections, causing severe morbidity and mortality worldwide and accounting for more than 50% of all S. aureus diseases. S. aureus used in our...
Antioxidant and Anti-urease Activity of Various Solvent Extracts of “Terminalia arjuna” Seeds
Background: Terminalia arjuna, a popular cardio curative plant. Present work emphasizes on the evaluation of antioxidant and anti-urease activity of different fractions extracts of Terminalia arjuna seeds. Methods: Six...
Treatment Persistence Associated with Typical versus Atypical Antipsychotics among Out-patients with Schizophrenia
Aim: The chronic nature of schizophrenia usually demands uninterrupted treatment in order to maintain optimal clinical and functional outcomes. It has been speculated that patients receiving atypical antipsychotics may p...
Anti-proliferative Effect of Chickpea Extract on Hela, MCF-7, Saos and Fibroblast Cell Lines
Background and Aim: The present study aimed to investigate the proliferation inhibitory effects of seed protein extract from chickpeas (Cicer arietinum L.) on cancer cell lines. Materials and Methods: The chickpea water...
Development and Validation of Liquid Chromatography Method for the Determination and Quantification of Impurities in Imiquimod
New stability indicating reverse phase high performance liquid chromatography (HPLC) method is developed for the determination of Imiquimod and its impurities. Separation is achieved on a C18 column (Inertsil-ODS3 4.6 × ...