Application of Radionuclides and Antibody-Drug Conjugates to Target Cancer
Journal Title: Cancer Studies & Molecular Medicine – Open Journal - Year 2014, Vol 1, Issue 1
Abstract
Radionuclide therapy and antibody-drug conjugates are used to locate and kill cancer cells by the utilisation of monoclonal antibodies. These bio-vectors are able to transport a cytotoxic drug payload and/or radiation in the form of alpha or beta particles to bind onto antigen specific cancer cells initiating apoptosis. This inaugural article aims to deliver a brief account of these targeted therapies in the treatment of oncological disease states such as leukaemia, non-Hodgkin’s lymphoma, neuroendocrine tumours, breast cancer and prostate cancer bone metastases.
Authors and Affiliations
Sean L. Kitson
Keywords
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- EP ID EP552502
- DOI 10.17140/CSMMOJ-1-102
- Views 98
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