Application of silymarin in human and animal medicine

Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2007, Vol 1, Issue 1

Abstract

Silymarin, the polyphenolic fraction from Milk Thistle ([i]Silybum marianum[/i]) and its main component silybinin, are used almost exclusively for hepatoprotection in humans. Silymarin offers good protection in various toxic models of experimental liver diseases in laboratory animals. It effects, by antioxidative, anti-inflammatory, antifibrotic, anti-lipid peroxidative, membrane stabilizing and liver regenerating mechanisms. Its clinical applications in humans comprise therapy in alcoholic liver diseases, liver cirrhosis, Amanita mushroom poisoning, viral hepatitis, toxic and drug-induced liver diseases. Recognition of new silymarin derivatives opens new ways for its application in liver therapy. Silymarin application in veterinary medicine is also reviewed.

Authors and Affiliations

Lidia Radko, Wojciech Cybulski

Keywords

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  • EP ID EP58561
  • DOI -
  • Views 85
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How To Cite

Lidia Radko, Wojciech Cybulski (2007). Application of silymarin in human and animal medicine. Journal of Pre-Clinical and Clinical Research, 1(1), 22-26. https://europub.co.uk/articles/-A-58561