Application of the polyvalent inactivated vaccine (Equi variant) against equine leptospirosis
Journal Title: Біологія тварин - Year 2018, Vol 20, Issue 2
Abstract
The article presents the results of research on the improvement of therapeutic and prophylactic measures for the latent course of leptospirosis in horses through the use of polyvalent inactivated vaccine. The vaccine was made in the laboratory of leptospirosis with the Museum of Microorganisms at the Institute of Veterinary Medicine National Academy of Agrarian Sciences of Ukraine. In one of the equestrian farms with a latent perception of leptospirosis, 150 horses were immunized. To study the immunization effectiveness of this vaccine and the immunity formation, 19-year-old horses were selected: 4 stallions-sires aged 6 to 12 years, 5 mares aged 6–10 years, 5 sport horses aged 3–5 years and 5 young ones at the age of 1–2 years. The vaccine against leptospirosis of horses contained the following serogroups, serovars and leptospiros strains, respectively: 1) Grippotyphosa — grippotyphosa VGNKI-1; 2) Canicola — canicola-VGNKI-3; 3) Icterohaemorrhagiae — icterohaemorrhagiae-VGNKI-2; 4) Australis-bratislava — Yez bratislava. The vaccine was injected intramuscularly at a dose of 5 cm3. For research of the microagglutination reaction blood was taken before vaccination, after 1, 2, 4, 5, 6.5 months after vaccination. At the 5th and 6th months after the application of the vaccine, in all the different age and sex groups of horses the titres of antibodies to the Australis, Hebdomadis, Sejroe serogroups increased, but we did not notice any clinical signs of the disease. That indicates a latent form of leptospirosis in the farm. In addition, the titres of antibodies increased as much as possible in the stallions-sires at the 5th month after vaccination, while the 6th month showed a downward trend. Meanwhile in mares, sport horses and young animals the antibody titers went up at the 5th and 6th months after vaccination. The obtained data testify that the use of polyvalent vaccine against lethospirosis of horses (Equi variant) contributes to the formation of intense immunity in the latent period of leptospirosis of horses and it is advisable to use it in horse farms.
Authors and Affiliations
O. E. Galatiuk, O. R. Kalnaus, V. O. Volynets, O. O. Kucheryavenko
Keywords
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- EP ID EP357774
- DOI 10.15407/animbiol20.02.024
- Views 95
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