Application of therapeutic hemapheresis and the adverse reactions
Journal Title: Chinese Journal of Blood Transfusion - Year 2024, Vol 37, Issue 10
Abstract
Objective To discuss the application of therapeutic hemapheresis in clinical therapy and to observe the adverse reactions. Methods 126 times of therapeutic hemapheresis were performed in 121 patients by Nangel blood cell separator. Consumables and apheresis procedures were selected according to different treatment needs of patients. The clinical therapeutic efficacy laboratory indicators and adverse reactions during the treatment process were analyzed, and corresponding measures were taken. Results Among 100 patients who underwent platelet rich plasma (PRP) treatment, the success rate of collection was 98%. The average PRP platelet level achieved (981.22±3.55)×109/L, and the average concentration multiple of PRP achieved (4.01±0.52) times. All patients obtain symptomatic relief after treatment with PRP. The level of hemoglobin and red blood cell count of 6 polycythemia vera patients and the level of platelet of 10 essential thrombocythemia patients all decreased after therapeutic hemapheresis combined with hydroxycarbamide, with significant difference (P<0.05). Five patients with preoperative autologous blood donation have been through the surgery successfully. Out of the 121 patients, 10(8.26%) experienced mild adverse reaction (8.26%), 15(12.40%) showed bruising and bleeding at puncture site, and 1(0.83%) had pseudoaneurysm. Conclusion Therapeutic hemapheresis has the advantages of good curative effect, high success rate and low incidence of adverse reactions, and can be applied in PRP collection, removal of blood pathological components and preoperative autologous blood donation.
Authors and Affiliations
Qiong WANG, Xiaofang LI, Lu LI, Zhangyong HE
Keywords
Related Articles
- EP ID EP749844
- DOI 10.13303/j.cjbt.issn.1004-549x.2024.10.015
- Views 37
- Downloads 0
Effect of RHAG variants identified in Chinese population on RHAG mRNA splicing in vitro
Objective To study the effect of RHAG variants identified in Chinese population on mRNA splicing by minigene splicing assay(MSA) in vitro. Methods The pSplicePOLR2G minigene expression plasmids were constructed for 10 RH...
Evaluation and improvement of blood station quality management system: based on external audit
Objective To identify the main unqualified items in the external audit of blood station quality management system (referred to as external audit), in order to take necessary measures to continuously improve the quality s...
Molecular mechanism of ABO bood group variation
Objective To study the relationship between ABO subtype, para-Bombay blood group and genotype, so as to explore the possible molecular mechanism of these two blood groups, and provide accurate genetic detection targets a...
Influence of blood donors' coagulation status in apheresis platelet aggregation in vitro
Objective To investigate whether the blood donors' coagulation status may lead to apheresis platelet aggregation in vitro. Methods Thirty blood donors with aggregation in apheresis platelets collected by AMICUS blood cel...
Establishment and application of performance appraisal system oriented to improve blood collection and supply
Objective To establish a comprehensive performance appraisal system, in order to promote blood collection, preparation and supply. Methods The performance reform leading group headed by the central leader was set up to m...