Apremilast: A new hope in psoriasis
Journal Title: IP Indian Journal of Clinical and Experimental Dermatology - Year 2018, Vol 4, Issue 3
Abstract
Introduction Psoriasis is a common chronic inflammatory skin disease that can have a significant impact on the quality of life of those who are afflicted due to chronicity of the disease and frequent remissions and relapse There is a vast array of drugs for the treatment Methotrexate cyclosporine and retinoids are the most commonly used conventional systemic drugs Newer studies provide insight into their more effective and safer use and as combination therapy with biologics Apremilast is an orally administered small molecule inhibitor of phosphodiesterase 4 PDE4 Apremilast 30mg twice daily reduced the severity of moderate to severe plaque psoriasis palmoplantar psoriasis and guttate psoriasisObjective To evaluate efficacy tolerability and adverse effects of apremilastMaterials and Methods A clinical trail was conducted in department of Skin VD of Saraswathi institute of medical college on 80 patients Apremilast was started after initial titration and followed for 8 weeksResults Out of 80 patients 73 patients completed the study of which 69 patients have responded well and 14 patient did not show satisfactory result No major side effect encountered during the studyConclusion Apremilast was effective in plaque psoriasis palmo plantar psoriasis and guttate psoriasis and is well tolerated with mild adverse effects Also the regular lab investigations as required in others systemic treatment modalities are avoidedKeywords Apremilast Plaque psoriasis Phosphodiesterase 4 PDE4 Guttate psoriasis Palmo plantar psoriasis
Authors and Affiliations
Sachin Agarwal, Amarjeet Singh Verma, Prashant Kumar Yadav, Megha Sharma, Harmeet Kaur
Keywords
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- EP ID EP488896
- DOI 10.18231/2581-4729.2018.0045
- Views 134
- Downloads 0
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