Aqueous Extract of Cyperus esculentus L. (Cyperaceae) Enhances Libido and Spermatogenesis in Male Wistar Rats
Journal Title: Tropical Journal of Natural Product Research - Year 2018, Vol 2, Issue 11
Abstract
Received 01 November 2018 Revised 23 November 2018 Accepted 24 November 2018 Published online 27 November 2018 Poor libido is often influenced by social, biological, and psychological factors. Cyperus esculentus (tiger nut), propagated by rhizome, basal bulb and tuber is used in the middle-east to stimulate libido. Hence, we investigated the influence of C. esculentus aqueous extract on mount frequency and ejaculatory latency and examined spermatogenic and testicular morphometry in male Wistar rats. Tubers of C. esculentus were prepared and processed, while crushed nuts were soaked in distilled water and filtered. The filtrate was concentrated to dryness using a rotary evaporator and lyophilized. Male rats were selected into groups (I to V; n = 5) and were fed with rat chow and water given ad libitum, while females were introduced much later (one male to a female) in an attenuated room, 10 minutes after treatment with graded doses (250 mg/kg, 500 mg/kg, 750 mg/kg and 1000 mg/kg) of the extract once daily for 30 days. Animals were monitored by two trained expert observers to determine their sex drive. Spermatogenic (sperm count, motility, morphology, viability, abnormality and pH) and morphometric (Seminiferous tubular diameter, size of interstices and epididymal epithelial thickness) parameters were determined. Mount frequency and ejaculatory latency were significantly reduced in treated rats (P < 0.001). Significant increase in richness of spermatozoa and morphometric parameters of testis and epididymis in treated rats were observed (P < 0.05). Histopathology was consistent with normal tissues. This study provides a rationale for the traditional use of tiger nut tubers against low sex drive in men.
Authors and Affiliations
Blessing E. Atoigwe-Ogeyemhe, Efosa B. Odigie, Peter U. Achukwu
Keywords
Related Articles
- EP ID EP499361
- DOI 10.26538/tjnpr/v2i11.2
- Views 108
- Downloads 0
Enzyme Inhibitory and Antioxidant Activity of Combination of Two Edible Mushrooms of Ganoderma lucidum and Pleurotus ostreatus
Received 04 April 2018 Revised 23 June 2018 Accepted 05 July 2018 Published online 08 July 2018 Edible mushrooms such as Ganoderma lucidum and Pleurotus ostreatus are of great significance in traditional medicine. This...
Antioxidant Potential of Phoenix dactylifera Linn Extract and its Effects on Calcium Channel Antagonist in the Treatment of Withdrawal Syndrome in Morphine Dependent Rats
Received 22 February 2018 Revised 05 July 2018 Accepted 06 July 2018 Published online 08 July 2018 Date fruit Phoenix dactylifera (Linn) is remarkably known for its nutritional and numerous health benefits that are lin...
Antiplasmodial and Acute Toxicity Studies of Fractions and Cassane-Type Diterpenoids from the Stem Bark of Caesalpinia pulcherrima (L.) Sw.
Received 08 March 2018 Revised 01 April 2018 Accepted 04 April 2018 Published online 07 April 2018 Malaria is a major public health disease affecting millions of people worldwide especially in subSaharan Africa, with a...
The Role of Metallothionein and Some Micronutrients in the Pathogenesis of HIV Infection: A Review
Received 12 June 2018 Revised 25 June 2018 Accepted 27 June 2018 Published online 08 July 2018 Human immunodeficiency virus (HIV) infection remains a major public health challenge especially in sub-Sahara Africa where t...
https://www.tjnpr.org/viewarticle.aspx?articleid=50
There is a growing concern of the potential risk of producing genetically defective sperm and transmitting germ-line mutations to progeny by fathers who prefer their children at old age. Men with male factor infertility...