Aqueous oxygen
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2011, Vol 28, Issue 4
Abstract
Administration of oxygen (O2) by ventilation may either fail to correct arterial hypoxemia or be limited by its potential for pulmonary toxicity at high inspired O2 concentrations. High levels of hyperoxemia may have utility in the treatment of regional tissue ischemia, but current methods for its implementation are impractical. Researchers have recently developed a bubbleless method for introducing O2 into the bloodstream, namely aqueous oxygen (AO). The concentration of O2 in AO is 1 to 3 mL O2/g, which is an order of magnitude greater than the O2 carrying capacity of blood. Rapid dilution of the AO effluent with the host liquid results in efficient oxygenation of hypoxemic liquids. The use of AO has been studied in the reperfusion of ischemic regions after percutaneous coronary intervention for acute myocardial infarction, mostly in animal models but also in four clinical trials, while its use for the relief of hypoxemic pulmonary hypertension is also being investigated. The primary experimental and clinical data related to AO use in myocardial reperfusion after percutaneous coronary intervention for acute myocardial infarction are contradictory. As for its use in pulmonary hypertension, the data from the first experimental model justify further research in more severe and chronic situations.
Authors and Affiliations
A. KOPITOPOULOU, C. DIMITROPOULOS
Keywords
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