Archachatina marginata Haemolymph Potentiates Hypoglycemic Effect by Mimicking Insulin in Streptozotocin-Induced Diabetic Rat
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 18, Issue 1
Abstract
Aims: This study investigates the hypoglycemic potential of Archachatina marginata haemolymph and its mechanism in streptozotocin -induced diabetic rats. Study Design: One factor experimental design. Place and Duration of Study: Department of Chemical Sciences, Joseph Ayo Babalola University, Ikeji Arakeji, Osun State, Nigeria between January to June, 2015. Methodology: The rats were set into four groups (n=5). Group 1 - Non-diabetic control (NDC), Group 2 - Diabetic Control (DC), Group 3 - Diabetic rats with 1 mL administration of snail haemolymph (DSS1), Group 4 - Diabetic rats with 2 mL snail haemolymph administration (DSS2). The blood glucose concentration of each rat was taken and thereafter, they were weighed and then administered with 55 mg/kg STZ in citrate buffer (pH 4.5) peritoneally non-diabetic control group (NDC). Rats with blood glucose level of 200 mg/dL and above were considered diabetic. Haemolymph of 1 mL and 2 mL were administered to rats in DSS1 and DSS2 respectively while DC received 2 mL distilled water for 14 consecutive days. Physiological orangs and blood samples were harvested for various analysis. Results: The A. marginata haemolymph significantly improved the plasma concentration of insulin and reduced plasma glucose level in a dose dependent manner P=.05. Conclusion: The A. marginata haemolymph has potential to exact hypoglycemic effect and improve the insulin concentration in streptozotocin induced diabetic rat.
Authors and Affiliations
S. K. Adeboye, A. T. Ogundajo, O. O. Ajayi, O. M. Oluba
Keywords
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- EP ID EP312893
- DOI 10.9734/JPRI/2017/33786
- Views 94
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